HLA-A80

HLA-A80 (A80) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α⁸⁰ subset of HLA-A α-chains. For A80, the alpha "A" chain are encoded by the HLA-A*80 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*8001. A80 and A*80 are almost synonymous in meaning.

Further information: History and naming of human leukocyte antigens

HLA-A80
(MHC Class I, A cell surface antigen)
HLA-A80
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*8001, β2-microglobulin
Older names	AX"BG"
Subtypes
Subtype allele Available structures A*80 *8001 {{{cNick2}}} *80{{{cAllele2}}} {{{cNick3}}} *80{{{cAllele3}}} {{{cNick4}}} *80{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

A80 is more common in West Central Africa. A80 is the least common HLA-A allele group.

Serotype

A80 recognition of some HLA A*80 gene products[2]

A*80	A80	A10	Sample
allele	%	%	size (N)
*8001	36	10	505

A80 HLA-A80 typing is poor. Most typing is done with SSP-PCR. Most of 8001 are detected with "Blank" serotype..

Distribution

HLA A*8001 frequencies

Study population	Freq.  (in %)[3]
Senegal Niokholo Mandenka	3.8
Zambia Lusaka	2.3
Cameroon Bamileke	1.9
Mali Bandiagara	1.5
South Africa Tswana	1.2
Spain Menorca	1.1
Cameroon Bakola Pygmy	1.0
Burkina Faso Fulani	1.0
Trinidad Africans	1.0
Tunisia	1.0
Bulgaria	0.9
Cape Verde Southeastern I…	0.8
Guinea Bissau	0.8
USA African Americans	0.8
Peru Arequipa	0.7
Turkey class I	0.7
Cameroon Beti	0.6
Spain Catalonia Girona	0.6
USA Caucasians (3)	0.6
Brazil	0.5
Brazil Belo Horizonte	0.5
Brazil Pernambuco State	0.5
Croatia pop2	0.5
Guatemala Mayans	0.4
Mongolia Buriat	0.4
Allele frequencies presented, only

Further reading

• Torimiro JN, Carr JK, Wolfe ND, et al. (2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens. 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
• Sanchez-Mazas A, Steiner QG, Grundschober C, Tiercy JM (October 2000). "The molecular determination of HLA-Cw alleles in the Mandenka (West Africa) reveals a close genetic relationship between Africans and Europeans". Tissue Antigens. 56 (4): 303–12. doi:10.1034/j.1399-0039.2000.560402.x. PMID 11098930.
• Cao K, Moormann AM, Lyke KE, et al. (April 2004). "Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci". Tissue Antigens. 63 (4): 293–325. doi:10.1111/j.0001-2815.2004.00192.x. PMID 15009803.
• Torimiro JN, Carr JK, Wolfe ND, et al. (January 2006). "HLA class I diversity among rural rainforest inhabitants in Cameroon: identification of A*2612-B*4407 haplotype". Tissue Antigens. 67 (1): 30–7. doi:10.1111/j.1399-0039.2005.00527.x. PMID 16451198.
• Crespí C, Milà J, Martínez-Pomar N, et al. (October 2002). "HLA polymorphism in a Majorcan population of Jewish descent: comparison with Majorca, Minorca, Ibiza (Balearic Islands) and other Jewish communities". Tissue Antigens. 60 (4): 282–91. doi:10.1034/j.1399-0039.2002.600402.x. PMID 12472657.

References

1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
2. Allele Query Form IMGT/HLA - European Bioinformatics Institute
3. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.