HLA-A66

HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A*66 allele group and the β-chain are encoded by B2M locus.[1] A66 and A*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43.

Further information: History and naming of human leukocyte antigens
HLA-A66
(MHC Class I, A cell surface antigen)
HLA-A66
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*66--, β2-microglobulin
Older namesA10
Subtypes
Subtype
allele
Available structures
A66.1 *6601
A66.2 *6602
{{{cNick3}}} *66{{{cAllele3}}}
{{{cNick4}}} *66{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
A66.3 *6603
{{{rnick2}}} *66{{{rallele2}}}
{{{rnick3}}} *66{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].

Serotype
A66 recognition of some HLA A*66 gene products[3]
A*66 A66 A10A26A34 Sample
allele%%%% size (N)
*66012010618799
*66023810427205
*660332771828

A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.

A*6601 Frequencies
HLA A*6601 frequencies
freq
ref.Population(%)
[4]Cameroon Sawa7.7
[4]Kenya Luo6.8
[4]Cameroon Sawa7.7
[4]Cameroon Bakola Pygmy5.8
[4]Cameroon Baka Pygmy5.0
[4]Kenya Nandi5.0
[4]Zimbabwe Harare Shona0.2
[4]Cameroon Baka Pygmy5.0
[4]Cameroon Beti4.6
[4]Cameroon Bamileke4.5
[4]India West Bhils4.0
[4]Zimbabwe Harere Shona3.8
[4]Uganda Kampala3.8
[4]India Mumbai Marathas2.5
[4]Cape Verde Northwestern2.5
[4]Czech republic2.4
[4]Morocco Nador Metalsa2.1
[4]Central Portugal2.0
[4]India West Parsis2.0
[4]South African Natal Zulu2.0
[4]Kenya1.7
[4]Tunisia Tunis1.7
[4]Guinea Bissau1.5
[4]Georgia Tibilisi1.4
[4]Zambia Lusaka1.2
[4]Italy Bergamo1.1
[4]Pakistan Karachi Parsi1.1
[4]Oman0.8
[4]Sudanese0.8
[4]Belgium0.5
[4]Southeast France0.4
[4]Mongolia Buriat0.4
[4]Wales0.2
HLA A*6602 frequencies
freq
ref.Population(%)
[4]South African Natal Zulu1.5
[4]Cameroon Yaounde1.1
[4]Cameroon Bamileke0.6
[4]Senegal Niokholo Mandenka0.5
[4]Kenya Nandi0.4
[4]Zimbabwe Harare Shona0.2
[4]Wales0.03
HLA A*6603 frequencies
freq
ref.Population(%)
[4]Cameroon Pygmy Baka10.0
[4]Cameroon Bakola Pygmy9.0
[4]Cameroon Sawa7.7
[4]CAR Mbenzele Pygmy2.8
[4]Zimbabwe Harare Shona0.2
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References
  1. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. Madrigal JA, Hildebrand WH, Belich MP, et al. (1993). "Structural diversity in the HLA-A10 family of alleles: correlations with serology". Tissue Antigens. 41 (2): 72–80. doi:10.1111/j.1399-0039.1993.tb01982.x. PMID 8475492.
  3. Allele Query Form IMGT/HLA - European Bioinformatics Institute
  4. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660. External link in |title= (help)
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