Fibrolase
Fibrolase (EC 3.4.24.72, fibrinolytic proteinase, Agkistrodon contortrix contortrix metalloproteinase, Agkistrodon contortrix contortrix venom metalloproteinase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of -Ala14-Leu- in insulin B chain and -Lys413-Leu- in alpha-chain of fibrinogen
| Fibrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.72 | ||||||||
| CAS number | 116036-70-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in the venom of the southern copperhead snake (Agkistrodon contortrix contortrix).
References
- Retzios AD, Markland FS (December 1988). "A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems". Thrombosis Research. 52 (6): 541–52. doi:10.1016/0049-3848(88)90127-2. PMID 3232124.
- Guan AL, Retzios AD, Henderson GN, Markland FS (September 1991). "Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix)". Archives of Biochemistry and Biophysics. 289 (2): 197–207. doi:10.1016/0003-9861(91)90462-r. PMID 1898066.
- Randolph A, Chamberlain SH, Chu HL, Retzios AD, Markland FS, Masiarz FR (May 1992). "Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom". Protein Science. 1 (5): 590–600. doi:10.1002/pro.5560010505. PMC 2142229. PMID 1304358.
- Loayza SL, Trikha M, Markland FS, Riquelme P, Kuo J (December 1994). "Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities". Journal of Chromatography B. 662 (2): 227–43. doi:10.1016/0378-4347(94)00202-9. PMID 7719479.
- Retzios AD, Markland FS (May 1994). "Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basiliscus basiliscus: cleavage site specificity towards the alpha-chain of fibrin". Thrombosis Research. 74 (4): 355–67. doi:10.1016/0049-3848(94)90151-1. PMID 8085237.
External links
- Fibrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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