EBI3

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.[5][6]

EBI3
Identifiers
Aliases	EBI3, IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDs	OMIM: 605816 MGI: 1354171 HomoloGene: 4207 GeneCards: EBI3
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,229,523 bp[1] End 4,237,528 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 D|17 29.08 cM Start 55,952,640 bp[2] End 55,957,022 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine receptor activity • cytokine activity • interleukin-27 receptor binding • GO:0001948 protein binding • ciliary neurotrophic factor receptor activity • cytokine binding Cellular component • extracellular region • cell membrane • membrane • extracellular • endoplasmic reticulum lumen • external side of plasma membrane • receptor complex • ciliary neurotrophic factor receptor complex • CNTFR-CLCF1 complex Biological process • T-helper 1 type immune response • T cell proliferation • humoral immune response • positive regulation of alpha-beta T cell proliferation • positive regulation of interferon-gamma biosynthetic process • regulation of receptor activity • interleukin-27-mediated signaling pathway • interleukin-35-mediated signaling pathway • ciliary neurotrophic factor-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10148	50498
Ensembl	ENSG00000105246	ENSMUSG00000003206
UniProt	Q14213	O35228
RefSeq (mRNA)	NM_005755	NM_015766
RefSeq (protein)	NP_005746	NP_056581
Location (UCSC)	Chr 19: 4.23 – 4.24 Mb	Chr 17: 55.95 – 55.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene was identified by the induction of its expression in B lymphocytes by Epstein-Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.[7]

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.[8] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.[7][9]

References

1. GRCh38: Ensembl release 89: ENSG00000105246 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003206 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EBI3 Epstein-Barr virus induced gene 3".
6. Devergne O, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, Birkenbach M (February 1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.
7. Collison LW, Workman CJ, Kuo TT, Boyd K, Wang Y, Vignali KM, Cross R, Sehy D, Blumberg RS, Vignali DA (November 2007). "The inhibitory cytokine IL-35 contributes to regulatory T-cell function". Nature. 450 (7169): 566–9. Bibcode:2007Natur.450..566C. doi:10.1038/nature06306. PMID 18033300.
8. Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N (September 2006). "Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells". Nat. Immunol. 7 (9): 929–36. doi:10.1038/ni1375. PMID 16906167.
9. Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, Liew FY (November 2007). "IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells". Eur. J. Immunol. 37 (11): 3021–9. doi:10.1002/eji.200737810. PMID 17874423.

Further reading

• Small RD (1976). "Letter: Statistical analysis of respiratory sensitivity to CO2". N. Engl. J. Med. 295 (7): 397. doi:10.1056/NEJM197608122950720. PMID 934235.
• Devergne O, Hummel M, Koeppen H, et al. (1996). "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes". J. Virol. 70 (2): 1143–53. doi:10.1128/JVI.70.2.1143-1153.1996. PMC 189923. PMID 8551575.
• Devergne O, Birkenbach M, Kieff E (1997). "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12041–6. doi:10.1073/pnas.94.22.12041. PMC 23696. PMID 9342359.
• Pflanz S, Timans JC, Cheung J, et al. (2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Larousserie F, Pflanz S, Coulomb-L'Herminé A, et al. (2004). "Expression of IL-27 in human Th1-associated granulomatous diseases". J. Pathol. 202 (2): 164–71. doi:10.1002/path.1508. PMID 14743498.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Gehlert T, Devergne O, Niedobitek G (2004). "Epstein-Barr virus (EBV) infection and expression of the interleukin-12 family member EBV-induced gene 3 (EBI3) in chronic inflammatory bowel disease". J. Med. Virol. 73 (3): 432–8. doi:10.1002/jmv.20109. PMID 15170639.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

External links

• EBI3 human gene location in the UCSC Genome Browser.
• EBI3 human gene details in the UCSC Genome Browser.