Digalactosyldiacylglycerol synthase
In enzymology, a digalactosyldiacylglycerol synthase (EC 2.4.1.241) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol UDP + 3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn- glycerol
| digalactosyldiacylglycerol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.241 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Thus, the two substrates of this enzyme are UDP-galactose and 3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol, whereas its 3 products are UDP, [[3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-diacyl-sn-]], and glycerol.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:3-(beta-D-galactosyl)-1,2-diacyl-sn-glycerol 6-alpha-galactosyltransferase. Other names in common use include DGD1, DGD2, DGDG synthase (ambiguous), UDP-galactose-dependent DGDG synthase, UDP-galactose-dependent digalactosyldiacylglycerol synthase, and UDP-galactose:MGDG galactosyltransferase. This enzyme participates in glycerolipid metabolism.
References
- Kelly AA, Dormann P (2002). "DGD2, an arabidopsis gene encoding a UDP-galactose-dependent digalactosyldiacylglycerol synthase is expressed during growth under phosphate-limiting conditions". J. Biol. Chem. 277 (2): 1166–73. doi:10.1074/jbc.M110066200. PMID 11696551.
- Hartel H, Dormann P, Benning C (2000). "DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10649–54. doi:10.1073/pnas.180320497. PMC 27079. PMID 10973486.
- Kelly AA, Froehlich JE, Dormann P (2003). "Disruption of the two digalactosyldiacylglycerol synthase genes DGD1 and DGD2 in Arabidopsis reveals the existence of an additional enzyme of galactolipid synthesis". Plant Cell. 15 (11): 2694–706. doi:10.1105/tpc.016675. PMC 280572. PMID 14600212.
- Benning C, Ohta H (2005). "Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants". J. Biol. Chem. 280 (4): 2397–400. doi:10.1074/jbc.R400032200. PMID 15590685.