DNQX

DNQX (6,7-dinitroquinoxaline-2,3-dione) is a competitive antagonist at AMPA and kainate receptors, two ionotropic glutamate receptor (iGluR) subfamilies.[1] It is used in a variety of molecular biology subfields, notably neurophysiology, to assist researchers in determining the properties of various types of ion channels and their potential applications in medicine.

DNQX

Names
IUPAC name 6,7-Dinitroquinoxaline-2,3(1H,4H)-dione
Identifiers
CAS Number	2379-57-9^N
3D model (JSmol)	Interactive image
ChemSpider	3123097^Y
DrugBank	DB03759^Y
PubChem CID	3899541
UNII	62T278S1MX
CompTox Dashboard (EPA)	DTXSID50274395
InChI InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)^Y Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N^Y InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) Key: RWVIMCIPOAXUDG-UHFFFAOYSA-N
SMILES O=c2[nH]c1cc(N(=O)=O)c(N(=O)=O)cc1[nH]c2=O
Properties
Chemical formula	C8H4N4O6
Molar mass	252.142 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

See also

• Quinoxalinedione
• CNQX

References

1. Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R (September 2010). "Glutamate receptor ion channels: structure, regulation, and function". Pharmacological Reviews. 62 (3): 405–96. doi:10.1124/pr.109.002451. PMC 2964903. PMID 20716669.

External links

• DNQX MSDS