Colforsin

Colforsin (INN) is a water-soluble derivative of forskolin.[1][2]

Colforsin

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 3-dimethylaminopropanoate
CAS Number	138605-00-2^Y
PubChem CID	444028
ChemSpider	392052^N
UNII	1F7A44V6OU
KEGG	D01697^Y
ChEMBL	ChEMBL52606^N
CompTox Dashboard (EPA)	DTXSID90930165
ECHA InfoCard	100.215.763
Chemical and physical data
Formula	C27H43NO8
Molar mass	509.640 g·mol^−1
3D model (JSmol)	Interactive image
SMILES CC(=O)O[C@H]1[C@H]([C@H]2C(CC[C@@H]([C@@]2([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C
InChI InChI=1S/C27H43NO8/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24/h10,17,20-22,30,33H,1,11-15H2,2-9H3/t17-,20-,21-,22-,24-,25-,26+,27-/m0/s1^N Key:RSOZZQTUMVBTMR-XGUNBQNXSA-N^N
^NY (what is this?)  (verify)

References

1. Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yokoyama M (August 1994). "Effect of NKH477, a new water-soluble forskolin derivative, on arterial-ventricular coupling and mechanical energy transduction in patients with left ventricular systolic dysfunction: comparison with dobutamine". J. Cardiovasc. Pharmacol. 24 (2): 310–6. doi:10.1097/00005344-199424020-00018. PMID 7526066.
2. Sanbe A, Takeo S (July 1995). "Effects of NKH477, a water-soluble forskolin derivative, on cardiac function in rats with chronic heart failure after myocardial infarction". J. Pharmacol. Exp. Ther. 274 (1): 120–6. PMID 7616388.