Cobyrinate a,c-diamide synthase
Cobyrinate a,c-diamide synthase (EC 6.3.5.11), cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction[1]
- 2 ATP + cobyrinate + 2 L-glutamine + 2 H2O 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)
- (1a) ATP + cobyrinate + L-glutamine + H2O ADP + phosphate + cobyrinate c-monamide + L-glutamate
- (1b) ATP + cobyrinate c-monamide + L-glutamine + H2O ADP + phosphate + cobyrinate a,c-diamide + L-glutamate
| Cobyrinate a,c-diamide synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 6.3.5.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is a glutamine amidotransferase, part of the biosynthetic pathway to cobalamin (vitamin B12) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.
See also
References
- Fresquet V, Williams L, Raushel FM (August 2004). "Mechanism of cobyrinic acid a,c-diamide synthetase from Salmonella typhimurium LT2". Biochemistry. 43 (33): 10619–27. doi:10.1021/bi048972x. PMID 15311923.
External links
- Cobyrinate+a,c-diamide+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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