Christine Orengo

Christine Anne Orengo, FRS is a Professor of Bioinformatics at University College London (UCL)[4][5][6][7] known for her work on protein structure, particularly the CATH database.[2][8] Orengo serves as president of the International Society for Computational Biology (ISCB), becoming the first woman to achieve the position in the history of the society.[9].

Christine Orengo

FRS
Christine Orengo in 2015 speaking at the Intelligent Systems for Molecular Biology (ISMB)/European Conference on Computational Biology (ECCB) conference in Dublin
Born
Christine Anne Orengo

(1955-06-22) 22 June 1955[1]
Alma mater
Known for
AwardsEMBO Membership (2014)[3]
Scientific career
Fields
Institutions
ThesisA study of the redox properties of haem in proteins and model systems (1984)
Websitewww.ucl.ac.uk/orengo-group

Education

Orengo studied Chemical Physics at the University of Bristol where she was awarded a Bachelor of Science degree. She continued her studies at the University of Aberdeen where she was awarded a Master of Science degree in Medical Physics in 1977 for research on the disruption of iron metabolism in laboratory rats with Yoshida sarcomas.[10] She was awarded a PhD for research on the redox properties of haem in proteins in 1984 from UCL.[11]

Career and research

Following her PhD, Orengo worked in industry before being appointed a postdoctoral researcher at the National Institute for Medical Research (NIMR) in Mill Hill where she worked until 1990.[8] She joined the department of biochemistry and molecular biology at UCL and in 1995 and was awarded a Medical Research Council (MRC) senior fellowship in Bioinformatics. She was promoted to Professor of Bioinformatics in 2002.[8]

Orengo's research analyses genes, proteins and biological systems using computational methods to classify proteins into evolutionary families. Her research has been funded by the Medical Research Council and the Biotechnology and Biological Sciences Research Council (BBSRC).[12]

Orengo is co-editor with David Jones and Janet Thornton of the textbook Bioinformatics: Genes, Proteins and Computers.[13] As of 2015, according to Google Scholar[4] and Scopus[5] her most cited work has been published in Nature,[14] Nucleic Acids Research,[15][16] Structure[2] and the Journal of Molecular Biology.[17][18] Her former doctoral students include Sonja Lehtinen[19][20] and Ian Sillitoe.[21]

Awards and honours

Orengo was elected a member of the European Molecular Biology Organization (EMBO) in 2014 and a Fellow of the Royal Society (FRS) in 2019.[3][22][23]

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References
  1. Christine Orengo at Library of Congress Authorities
  2. Orengo, C. A.; Michie, A. D.; Jones, S.; Jones, D. T.; Swindells, M. B.; Thornton, J. M. (1997). "CATH – a hierarchic classification of protein domain structures". Structure. 5 (8): 1093–1109. doi:10.1016/S0969-2126(97)00260-8. PMID 9309224.
  3. Anon (2015). "The EMBO Pocket Directory" (PDF). Heidelberg: European Molecular Biology Organization. Archived from the original (PDF) on 16 March 2015.
  4. Christine Orengo publications indexed by Google Scholar
  5. Christine Orengo publications indexed by the Scopus bibliographic database. (subscription required)
  6. Christine Orengo publications from Europe PubMed Central
  7. Christine Orengo's ORCID 0000-0002-7141-8936
  8. "Professor Christine Orengo". University College London. Archived from the original on 19 May 2015.
  9. "Officers and Directors". Iscb.org. Retrieved 29 February 2020.
  10. Orengo, Christine Anne (1977). Disruption of iron metabolism in rats with Yoshida sarcomas (MSc thesis). University of Aberdeen. OCLC 646442339.
  11. Orengo, Christine Anne (1984). A study of the redox properties of haem in proteins and model systems. london.ac.uk (PhD thesis). University College London. OCLC 927065626.
  12. "UK Government research grants awarded to Christine Orengo". Research Councils UK. 27 November 2015. Archived from the original on 27 November 2015.
  13. Bioinformatics: Genes, Proteins and Computers. BIOS. 2003. ISBN 1859960545.
  14. Orengo, Christine Anne; Jones, David T.; Thornton, Janet M. (1994). "Protein superfamilles and domain superfolds". Nature. 372 (6507): 631–634. doi:10.1038/372631a0. ISSN 0028-0836. PMID 7990952.
  15. Hunter, S.; Apweiler, R.; Attwood, T.; Bairoch, A.; Bateman, A.; Binns, D.; Bork, P.; Das, U.; Daugherty, L.; Duquenne, L.; Finn, R. D.; Gough, J.; Haft, D.; Hulo, N.; Kahn, D.; Kelly, E.; Laugraud, A.; Letunic, I.; Lonsdale, D.; Lopez, R.; Madera, M.; Maslen, J.; McAnulla, C.; McDowall, J.; Mistry, J.; Mitchell, A.; Mulder, N.; Natale, D.; Orengo, C.; Quinn, A. F. (January 2009). "InterPro: the integrative protein signature database". Nucleic Acids Research. 37 (Database issue): D211–D215. doi:10.1093/nar/gkn785. ISSN 0305-1048. PMC 2686546. PMID 18940856.
  16. Hunter, S.; Jones, P.; Mitchell, A.; Apweiler, R.; Attwood, T. K.; Bateman, A.; Bernard, T.; Binns, D.; Bork, P.; Burge, S.; De Castro, E.; Coggill, P.; Corbett, M.; Das, U.; Daugherty, L.; Duquenne, L.; Finn, R. D.; Fraser, M.; Gough, J.; Haft, D.; Hulo, N.; Kahn, D.; Kelly, E.; Letunic, I.; Lonsdale, D.; Lopez, R.; Madera, M.; Maslen, J.; McAnulla, C.; McDowall, J. (2011). "InterPro in 2011: New developments in the family and domain prediction database". Nucleic Acids Research. 40 (Database issue): D306–D312. doi:10.1093/nar/gkr948. PMC 3245097. PMID 22096229.
  17. Todd, Annabel E; Orengo, Christine A; Thornton, Janet M (2001). "Evolution of function in protein superfamilies, from a structural perspective". Journal of Molecular Biology. 307 (4): 1113–1143. doi:10.1006/jmbi.2001.4513. ISSN 0022-2836. PMID 11286560. S2CID 14355820.
  18. Taylor, William R.; Orengo, Christine Anne (1989). "Protein structure alignment". Journal of Molecular Biology. 208 (1): 1–22. doi:10.1016/0022-2836(89)90084-3. ISSN 0022-2836. PMID 2769748.
  19. Lehtinen, Sonja; Bähler, Jürg; Orengo, Christine (2015). "Co-Expression Network Models Suggest that Stress Increases Tolerance to Mutations". Scientific Reports. 5: 16726. doi:10.1038/srep16726. ISSN 2045-2322. PMC 4644955. PMID 26568486.
  20. "Orengo lab alumni". University College London. 22 May 2015. Archived from the original on 22 May 2015.
  21. Sillitoe, Ian (2003). Consensus templates for protein structure recognition. london.ac.uk (PhD thesis). University College London. OCLC 500146824. EThOS 404942.
  22. "EMBO member: Christine Anne Orengo". Heidelberg: EMBO. Archived from the original on 6 December 2015.
  23. Anon (2019). "Professor Christine Orengo FRS". royalsociety.org. London. Archived from the original on 24 April 2019. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
    “All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)

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