Bothrolysin

Bothrolysin (EC 3.4.24.50, Bothrops metalloendopeptidase J, J protease) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Cleavage of Gln4-His, Ser9-His and Ala14-Leu of insulin B chain and Pro-Phe of angiotensin I
Bothrolysin
Identifiers
EC number3.4.24.50
CAS number443890-65-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This endopeptidase is present in the venom of the jararaca snake (Bothrops jararaca).

References

  1. Tanizaki MM, Zingali RB, Kawazaki H, Imajoh S, Yamazaki S, Suzuki K (1989). "Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca)". Toxicon. 27 (7): 747–55. doi:10.1016/0041-0101(89)90041-x. PMID 2781574.
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