Beta-Lytic metalloendopeptidase

Beta-lytic metalloendopeptidase (EC 3.4.24.32, Myxobacter beta-lytic proteinase, achromopeptidase component, beta-lytic metalloproteinase, beta-lytic protease, Myxobacterium sorangium beta-lytic proteinase, Myxobacter495 beta-lytic proteinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of N-acetylmuramoyl-Ala, and of the insulin B chain at Gly23-Phe > Val18-Cya
Beta-lytic metalloendopeptidase
Identifiers
EC number3.4.24.32
CAS number37288-92-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is present in Achromobacter lyticus and Lysobacter enzymogenes.

References

  1. Whitaker DR, Roy C, Tsai CS, Jurásek L (December 1965). "Lytic enzymes of Sorangium sp. A comparison of the proteolytic properties of the alpha- and beta-lytic proteases". Canadian Journal of Biochemistry. 43 (12): 1961–70. doi:10.1139/o65-219. PMID 5880182.
  2. Whitaker DR, Roy C (June 1967). "Concerning the nature of the alpha- and beta-lytic proteases of Sorangium sp". Canadian Journal of Biochemistry. 45 (6): 911–6. doi:10.1139/o67-101. PMID 6034704.
  3. Li SL, Norioka S, Sakiyama F (November 1990). "Molecular cloning and nucleotide sequence of the beta-lytic protease gene from Achromobacter lyticus". Journal of Bacteriology. 172 (11): 6506–11. doi:10.1128/jb.172.11.6506-6511.1990. PMC 526839. PMID 2228973.
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