Atrolysin F

Atrolysin F (EC 3.4.24.45, Crotalus atrox metalloendopeptidase, hemorrhagic toxin f, Crotalus atrox metalloendopeptidase f) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Cleavage of Val2-Asn, Gln4-His, Leu6-Cys, His10-Leu, Ala14-Leu and Tyr16-Leu bonds in insulin B chain
Atrolysin F
Identifiers
EC number3.4.24.45
CAS number172306-52-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).

References

  1. Nikai T, Mori N, Kishida M, Sugihara H, Tu AT (June 1984). "Isolation and biochemical characterization of hemorrhagic toxin f from the venom of Crotalus atrox (western diamondback rattlesnake)". Archives of Biochemistry and Biophysics. 231 (2): 309–19. doi:10.1016/0003-9861(84)90393-x. PMID 6375570.
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