Atrolysin B

Atrolysin B (EC 3.4.24.41, Crotalus atrox metalloendopeptidase b, hemorrhagic toxin b, Ht-b) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves -Ser bonds in glucagon
Atrolysin B
Identifiers
EC number3.4.24.41
CAS number172306-48-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is present in the western diamondback rattlesnake (Crotalus atrox).

References

  1. Bjarnason JB, Tu AT (August 1978). "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry. 17 (16): 3395–404. doi:10.1021/bi00609a033. PMID 210790.
  2. Bjarnason JB, Hamilton D, Fox JW (May 1988). "Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom". Biological Chemistry Hoppe-Seyler. 369 Suppl: 121–9. PMID 3060135.
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