Anorexia nervosa

Anorexia nervosa, often referred to simply as anorexia,[11] is an eating disorder, characterized by low weight, food restriction, fear of gaining weight, and a strong desire to be thin.[1] Many people with anorexia see themselves as overweight even though they are, in fact, underweight.[1][2] They often deny that they have a problem with low weight.[3] They weigh themselves frequently, eat small amounts, and only eat certain foods.[1] Some exercise excessively, force themselves to vomit, or use laxatives to produce weight loss.[1] Complications may include osteoporosis, infertility, and heart damage, among others.[1] Women will often stop having menstrual periods.[3] In extreme cases, people with anorexia who continually refuse significant dietary intake and weight restoration interventions may be fed by force under restraint via nasogastric tube within specialist psychiatric hospitals.[12]

"Anorexia" and "Anorexic" redirect here. For lack of appetite, see Anorexia (symptom). For the medication, see Anorectic. For other uses, see Anorexia (disambiguation).

Anorexia nervosa
Other names	Anorexia
"Miss A—" depicted in 1866 and in 1870 after treatment. She was one of the earliest case studies of anorexia. From the published medical papers of Sir William Gull.
Specialty	Psychiatry, Clinical psychology
Symptoms	Low weight, fear of gaining weight, strong desire to be thin, food restrictions[1]
Complications	Osteoporosis, infertility, heart damage, suicide[1]
Usual onset	Teen years to young adulthood[1]
Causes	Unknown[2]
Risk factors	Family history, high-level athletics, modelling, dancing[2][3][4]
Differential diagnosis	Body dysmorphic disorder, bulimia nervosa, substance use disorder, hyperthyroidism, inflammatory bowel disease, dysphagia, cancer[5][6]
Treatment	Cognitive behavioral therapy, hospitalisation to restore weight[1][7]
Prognosis	5% risk of death over 10 years[3][8]
Frequency	2.9 million (2015)[9]
Deaths	600 (2015)[10]

The cause is currently unknown.[2] There appear to be some genetic components with identical twins more often affected than non-identical twins.[2] Cultural factors also appear to play a role with societies that value thinness having higher rates of disease.[3] Additionally, it occurs more commonly among those involved in activities that value thinness such as high-level athletics, modelling, and dancing.[3][4] Anorexia often begins following a major life-change or stress-inducing event.[3] The diagnosis requires a significantly low weight.[3] The severity of disease is based on body mass index (BMI) in adults with mild disease having a BMI of greater than 17, moderate a BMI of 16 to 17, severe a BMI of 15 to 16, and extreme a BMI less than 15.[3] In children a BMI for age percentile of less than the 5th percentile is often used.[3]

Treatment of anorexia involves restoring a healthy weight, treating the underlying psychological problems, and addressing behaviors that promote the problem.[1] While medications do not help with weight gain, they may be used to help with associated anxiety or depression.[1] A number of types of therapy may be useful, such as cognitive behavioral therapy or an approach where parents assume responsibility for feeding their child known as Maudsley family therapy.[1][13] Sometimes people require admission to a hospital to restore weight.[7] Evidence for benefit from nasogastric tube feeding, however is unclear;[14] such an intervention may be highly distressing for both anorexia patients and healthcare staff when administered against the patient's will under restraint.[12] Some people with anorexia will just have a single episode and recover while others may have many episodes over years.[7] Many complications improve or resolve with regaining of weight.[7]

Globally, anorexia is estimated to affect 2.9 million people as of 2015.[9] It is estimated to occur in 0.9% to 4.3% of women and 0.2% to 0.3% of men in Western countries at some point in their life.[15] About 0.4% of young women are affected in a given year and it is estimated to occur ten times more commonly among women than men.[3][15] Rates in most of the developing world are unclear.[3] Often it begins during the teen years or young adulthood.[1] While anorexia became more commonly diagnosed during the 20th century it is unclear if this was due to an increase in its frequency or simply better diagnosis.[2] In 2013 it directly resulted in about 600 deaths globally, up from 400 deaths in 1990.[16] Eating disorders also increase a person's risk of death from a wide range of other causes, including suicide.[1][15] About 5% of people with anorexia die from complications over a ten-year period, a nearly six times increased risk.[3][8] The term "anorexia nervosa" was first used in 1873 by William Gull to describe this condition.[17]

Signs and symptoms

The back of a person with anorexia

Anorexia nervosa is an eating disorder characterized by attempts to lose weight, to the point of starvation. A person with anorexia nervosa may exhibit a number of signs and symptoms, the type and severity of which may vary and may be present but not readily apparent.[18]

Anorexia nervosa, and the associated malnutrition that results from self-imposed starvation, can cause complications in every major organ system in the body.[19] Hypokalaemia, a drop in the level of potassium in the blood, is a sign of anorexia nervosa.[20][21] A significant drop in potassium can cause abnormal heart rhythms, constipation, fatigue, muscle damage and paralysis.[22]

Symptoms may include:

• A low body mass index for one's age and height.
• Amenorrhea, a symptom that occurs after prolonged weight loss; causing menstruation to stop, hair to become brittle, and skin to become yellow and unhealthy.
• Fear of even the slightest weight gain; taking all precautionary measures to avoid weight gain or becoming "overweight".[23]
• Rapid, continuous weight loss.[24]
• Lanugo: soft, fine hair growing over the face and body.[21]
• An obsession with counting calories and monitoring fat contents of food.
• Preoccupation with food, recipes, or cooking; may cook elaborate dinners for others, but not eat the food themselves or consume a very small portion.
• Food restrictions despite being underweight or at a healthy weight.
• Food rituals, such as cutting food into tiny pieces, refusing to eat around others and hiding or discarding of food.
• Purging: May use laxatives, diet pills, ipecac syrup, or water pills to flush food out of their system after eating or may engage in self-induced vomiting though this is a more common symptom of bulimia.
• Excessive exercise[25] including micro-exercising, for example making small persistent movements of fingers or toes.[26]
• Perception of self as overweight, in contradiction to an underweight reality.
• Intolerance to cold and frequent complaints of being cold; body temperature may lower (hypothermia) in an effort to conserve energy due to malnutrition.[27]
• Hypotension or orthostatic hypotension.
• Bradycardia or tachycardia.
• Depression, anxiety disorders and insomnia.
• Solitude: may avoid friends and family and become more withdrawn and secretive.
• Abdominal distension.
• Halitosis (from vomiting or starvation-induced ketosis).
• Dry hair and skin, as well as hair thinning.
• Chronic fatigue.[23]
• Rapid mood swings.
• Having feet discoloration causing an orange appearance.
• Having severe muscle tension, aches and pains.
• Evidence/habits of self harming or self-loathing.
• Admiration of thinner people.
• Infertility.

Interoceptive

Interoception involves the conscious and unconscious sense of the internal state of the body, and it has an important role in homeostasis and regulation of emotions.[28] Aside from noticeable physiological dysfunction, interoceptive deficits also prompt individuals with anorexia to concentrate on distorted perceptions of multiple elements of their body image.[29] This exists in both people with anorexia and in healthy individuals due to impairment in interoceptive sensitivity and interoceptive awareness.[29]

Aside from weight gain and outer appearance, people with anorexia also report abnormal bodily functions such as indistinct feelings of fullness.[30] This provides an example of miscommunication between internal signals of the body and the brain. Due to impaired interoceptive sensitivity, powerful cues of fullness may be detected prematurely in highly sensitive individuals, which can result in decreased calorie consumption and generate anxiety surrounding food intake in anorexia patients.[31] People with anorexia also report difficulty identifying and describing their emotional feelings and the inability to distinguish emotions from bodily sensations in general, called alexithymia.[30]

Interoceptive awareness and emotion are deeply intertwined, and could mutually impact each other in abnormalities.[31] Anorexia patients also exhibit emotional regulation difficulties that ignite emotionally-cued eating behaviors, such as restricting food or excessive exercising.[31] Impaired interoceptive sensitivity and interoceptive awareness can lead anorexia patients to adapt distorted interpretations of weight gain that are cued by physical sensations related to digestion (e.g., fullness).[31] Combined, these interoceptive and emotional elements could together trigger maladaptive and negatively reinforced behavioral responses that assist in the maintenance of anorexia.[31] In addition to metacognition, people with anorexia also have difficulty with social cognition including interpreting others’ emotions, and demonstrating empathy.[32] Abnormal interoceptive awareness and interoceptive sensitivity shown through all of these examples have been observed so frequently in anorexia that they have become key characteristics of the illness.[30]

Associated problems

Other psychological issues may factor into anorexia nervosa; some fulfill the criteria for a separate Axis I diagnosis or a personality disorder which is coded Axis II and thus are considered comorbid to the diagnosed eating disorder. Some people have a previous disorder which may increase their vulnerability to developing an eating disorder and some develop them afterwards.[33] The presence of Axis I or Axis II psychiatric comorbidity has been shown to affect the severity and type of anorexia nervosa symptoms in both adolescents and adults.[34]

Obsessive-compulsive disorder (OCD) and obsessive-compulsive personality disorder (OCPD) are highly comorbid with AN, particularly the restrictive subtype.[35] OCPD is linked with more severe symptomatology and worse prognosis.[36] The causality between personality disorders and eating disorders has yet to be fully established.[37] Other comorbid conditions include depression,[38] alcoholism,[39] borderline and other personality disorders,[40][41] anxiety disorders,[42] attention deficit hyperactivity disorder,[43] and body dysmorphic disorder (BDD).[44] Depression and anxiety are the most common comorbidities,[45] and depression is associated with a worse outcome.[45]

Autism spectrum disorders occur more commonly among people with eating disorders than in the general population.[46] Zucker et al. (2007) proposed that conditions on the autism spectrum make up the cognitive endophenotype underlying anorexia nervosa and appealed for increased interdisciplinary collaboration.[47]

Causes

Dysregulation of the serotonin pathways has been implicated in the cause and mechanism of anorexia.[48]

There is evidence for biological, psychological, developmental, and sociocultural risk factors, but the exact cause of eating disorders is unknown.[48]

Genetic

Genetic correlations of anorexia with psychiatric and metabolic traits.

Anorexia nervosa is highly heritable.[48] Twin studies have shown a heritability rate of between 28 and 58%.[49] First degree relative of those with anorexia have roughly 12 times the risk of developing anorexia.[50] Association studies have been performed, studying 128 different polymorphisms related to 43 genes including genes involved in regulation of eating behavior, motivation and reward mechanics, personality traits and emotion. Consistent associations have been identified for polymorphisms associated with agouti-related peptide, brain derived neurotrophic factor, catechol-o-methyl transferase, SK3 and opioid receptor delta-1.[51] Epigenetic modifications, such as DNA methylation, may contribute to the development or maintenance of anorexia nervosa, though clinical research in this area is in its infancy.[52][53]

A 2019 study found a genetic relationship with mental disorders, such as schizophrenia, obsessive–compulsive disorder, anxiety disorder and depression; and metabolic functioning with a negative correlation with fat mass, type 2 diabetes and leptin.[54]

Environmental

Obstetric complications: prenatal and perinatal complications may factor into the development of anorexia nervosa, such as preterm birth,[55] maternal anemia, diabetes mellitus, preeclampsia, placental infarction, and neonatal heart abnormalities.[56] Neonatal complications may also have an influence on harm avoidance, one of the personality traits associated with the development of AN.

Neuroendocrine dysregulation: altered signalling of peptides that facilitate communication between the gut, brain and adipose tissue, such as ghrelin, leptin, neuropeptide Y and orexin, may contribute to the pathogenesis of anorexia nervosa by disrupting regulation of hunger and satiety.[57][58]

Gastrointestinal diseases: people with gastrointestinal disorders may be more at risk of developing disorders of eating practices than the general population, principally restrictive eating disturbances.[59] An association of anorexia nervosa with celiac disease has been found.[60] The role that gastrointestinal symptoms play in the development of eating disorders seems rather complex. Some authors report that unresolved symptoms prior to gastrointestinal disease diagnosis may create a food aversion in these persons, causing alterations to their eating patterns. Other authors report that greater symptoms throughout their diagnosis led to greater risk. It has been documented that some people with celiac disease, irritable bowel syndrome or inflammatory bowel disease who are not conscious about the importance of strictly following their diet, choose to consume their trigger foods to promote weight loss. On the other hand, individuals with good dietary management may develop anxiety, food aversion and eating disorders because of concerns around cross contamination of their foods.[59] Some authors suggest that medical professionals should evaluate the presence of an unrecognized celiac disease in all people with eating disorder, especially if they present any gastrointestinal symptom (such as decreased appetite, abdominal pain, bloating, distension, vomiting, diarrhea or constipation), weight loss, or growth failure; and also routinely ask celiac patients about weight or body shape concerns, dieting or vomiting for weight control, to evaluate the possible presence of eating disorders,[60] especially in women.[61]

Studies have hypothesized the continuance of disordered eating patterns may be epiphenomena of starvation. The results of the Minnesota Starvation Experiment showed normal controls exhibit many of the behavioral patterns of AN when subjected to starvation. This may be due to the numerous changes in the neuroendocrine system, which results in a self-perpetuating cycle.[62][63][64]

Anorexia nervosa is more likely to occur in a person's pubertal years. Some explanatory hypotheses for the rising prevalence of eating disorders in adolescence are "increase of adipose tissue in girls, hormonal changes of puberty, societal expectations of increased independence and autonomy that are particularly difficult for anorexic adolescents to meet; [and] increased influence of the peer group and its values."[65]

Psychological

Early theories of the cause of anorexia linked it to childhood sexual abuse or dysfunctional families;[66][67] evidence is conflicting, and well-designed research is needed.[48] The fear of food is known as sitiophobia,[68] cibophobia,[69] and is part of the differential diagnosis.[70][71] Other psychological causes of anorexia include low self-esteem, feeling like there is lack of control, depression, anxiety, and loneliness.[72]

Sociological

Anorexia nervosa has been increasingly diagnosed since 1950;[73] the increase has been linked to vulnerability and internalization of body ideals.[65] People in professions where there is a particular social pressure to be thin (such as models and dancers) were more likely to develop anorexia,[74] and those with anorexia have much higher contact with cultural sources that promote weight loss.[75] This trend can also be observed for people who partake in certain sports, such as jockeys and wrestlers.[76] There is a higher incidence and prevalence of anorexia nervosa in sports with an emphasis on aesthetics, where low body fat is advantageous, and sports in which one has to make weight for competition.[77] Family group dynamics can play a role in the cause of anorexia.[78] When there is a constant pressure from people to be thin, teasing and bullying can cause low self-esteem and other psychological symptoms.[72]

Media effects

Persistent exposure to media that presents body ideals may constitute a risk factor for body dissatisfaction and anorexia nervosa. The cultural ideal for body shape for men versus women continues to favor slender women and athletic, V-shaped muscular men. A 2002 review found that, of the magazines most popular among people aged 18 to 24 years, those read by men, unlike those read by women, were more likely to feature ads and articles on shape than on diet.[79] Body dissatisfaction and internalization of body ideals are risk factors for anorexia nervosa that threaten the health of both male and female populations.[80]

Websites that stress the importance of attainment of body ideals extol and promote anorexia nervosa through the use of religious metaphors, lifestyle descriptions, "thinspiration" or "fitspiration" (inspirational photo galleries and quotes that aim to serve as motivators for attainment of body ideals).[81] Pro-anorexia websites reinforce internalization of body ideals and the importance of their attainment.[81]

The media portray a false view of what people truly look like. In magazines and movies and even on billboards most of the actors/models are digitally altered in multiple ways. People then strive to look like these "perfect" role models when in reality they are not near perfection themselves.[82]

Mechanisms

Evidence from physiological, pharmacological and neuroimaging studies suggest serotonin may play a role in anorexia. While acutely ill, metabolic changes may produce a number of biological findings in people with anorexia that are not necessarily causative of the anorexic behavior. For example, abnormal hormonal responses to challenges with serotonergic agents have been observed during acute illness, but not recovery. Nevertheless, increased cerebrospinal fluid concentrations of 5-hydroxyindoleacetic acid (a metabolite of serotonin), and changes in anorectic behavior in response to tryptophan depletion (a metabolic precursor to serotonin) support a role in anorexia. The binding potential of 5-HT_2A receptors and 5-HT_1A receptors have been reportedly decreased and increased respectively in a number of cortical regions. While these findings may be confounded by comorbid psychiatric disorders, taken as a whole they indicate serotonin in anorexia.[83][84] These alterations in serotonin have been linked to traits characteristic of anorexia such as obsessiveness, anxiety, and appetite dysregulation.[64]

Neuroimaging studies investigating the functional connectivity between brain regions have observed a number of alterations in networks related to cognitive control, introspection, and sensory function. Alterations in networks related to the dorsal anterior cingulate cortex may be related to excessive cognitive control of eating related behaviors. Similarly, altered somatosensory integration and introspection may relate to abnormal body image.[85] A review of functional neuroimaging studies reported reduced activations in "bottom up" limbic region and increased activations in "top down" cortical regions which may play a role in restrictive eating.[86]

Compared to controls, recovered anorexics show reduced activation in the reward system in response to food, and reduced correlation between self reported liking of a sugary drink and activity in the striatum and ACC. Increased binding potential of ¹¹C radiolabelled raclopride in the striatum, interpreted as reflecting decreased endogenous dopamine due to competitive displacement, has also been observed.[87]

Structural neuroimaging studies have found global reductions in both gray matter and white matter, as well as increased cerebrospinal fluid volumes. Regional decreases in the left hypothalamus, left inferior parietal lobe, right lentiform nucleus and right caudate have also been reported[88] in acutely ill patients. However, these alterations seem to be associated with acute malnutrition and largely reversible with weight restoration, at least in nonchronic cases in younger people.[89] In contrast, some studies have reported increased orbitofrontal cortex volume in currently ill and  in recovered patients, although findings are inconsistent. Reduced white matter integrity in the fornix has also been reported.[90]

Diagnosis

A diagnostic assessment includes the person's current circumstances, biographical history, current symptoms, and family history. The assessment also includes a mental state examination, which is an assessment of the person's current mood and thought content, focusing on views on weight and patterns of eating.

DSM-5

Anorexia nervosa is classified under the Feeding and Eating Disorders in the latest revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM 5). There is no specific BMI cutoff that defines low weight required for the diagnosis of anorexia nervosa.[91][3]

The diagnostic criteria for anorexia nervosa (all of which needing to be meet for diagnosis) include:[7]

• Restriction of energy intake relative to requirements leading to a low body weight.
• Intense fear of gaining weight or persistent behaviors that interfere with gaining weight.
• Disturbance in the way a person's weight or body shape is experienced or a lack of recognition about the risks of the low body weight.

Relative to the previous version of the DSM (DSM-IV-TR), the 2013 revision (DSM5) reflects changes in the criteria for anorexia nervosa, most notably that of the amenorrhea criterion being removed.[7][92] Amenorrhea was removed for several reasons: it does not apply to males, it is not applicable for females before or after the age of menstruation or taking birth control pills, and some women who meet the other criteria for AN still report some menstrual activity.[7]

Subtypes

There are two subtypes of AN:[19][93]

• Binge-eating/purging type: the individual utilizes binge eating or displays purging behavior as a means for losing weight.[93] It is different from bulimia nervosa in terms of the individual's weight. An individual with binge-eating/purging type anorexia can maintain a healthy or normal weight, but is usually significantly underweight. People with bulimia nervosa on the other hand can sometimes be overweight.[23]
• Restricting type: the individual uses restricting food intake, fasting, diet pills, or exercise as a means for losing weight;[19] they may exercise excessively to keep off weight or prevent weight gain, and some individuals eat only enough to stay alive.[19][23] In the restrictive type, there are no recurrent episodes of binge-eating or purging present.[91]

Levels of severity

Body mass index (BMI) is used by the DSM-5 as an indicator of the level of severity of anorexia nervosa. The DSM-5 states these as follows:[94]

• Mild: BMI of greater than 17
• Moderate: BMI of 16–16.99
• Severe: BMI of 15–15.99
• Extreme: BMI of less than 15

Investigations

Medical tests to check for signs of physical deterioration in anorexia nervosa may be performed by a general physician or psychiatrist, including:

• Complete Blood Count (CBC): a test of the white blood cells, red blood cells and platelets used to assess the presence of various disorders such as leukocytosis, leukopenia, thrombocytosis and anemia which may result from malnutrition.[95]
• Urinalysis: a variety of tests performed on the urine used in the diagnosis of medical disorders, to test for substance abuse, and as an indicator of overall health[96]
• Chem-20: Chem-20 also known as SMA-20 a group of twenty separate chemical tests performed on blood serum. Tests include cholesterol, protein and electrolytes such as potassium, chlorine and sodium and tests specific to liver and kidney function.[97]
• Glucose tolerance test: Oral glucose tolerance test (OGTT) used to assess the body's ability to metabolize glucose. Can be useful in detecting various disorders such as diabetes, an insulinoma, Cushing's Syndrome, hypoglycemia and polycystic ovary syndrome.[98]
• Serum cholinesterase test: a test of liver enzymes (acetylcholinesterase and pseudocholinesterase) useful as a test of liver function and to assess the effects of malnutrition.[99]
• Liver Function Test: A series of tests used to assess liver function some of the tests are also used in the assessment of malnutrition, protein deficiency, kidney function, bleeding disorders, and Crohn's Disease.[100]
• Luteinizing hormone (LH) response to gonadotropin-releasing hormone (GnRH): Tests the pituitary glands' response to GnRh, a hormone produced in the hypothalamus. Hypogonadism is often seen in anorexia nervosa cases.[20]
• Creatine kinase (CK) test: measures the circulating blood levels of creatine kinase an enzyme found in the heart (CK-MB), brain (CK-BB) and skeletal muscle (CK-MM).[101]
• Blood urea nitrogen (BUN) test: urea nitrogen is the byproduct of protein metabolism first formed in the liver then removed from the body by the kidneys. The BUN test is primarily used to test kidney function. A low BUN level may indicate the effects of malnutrition.[102]
• BUN-to-creatinine ratio: A BUN to creatinine ratio is used to predict various conditions. A high BUN/creatinine ratio can occur in severe hydration, acute kidney failure, congestive heart failure, and intestinal bleeding. A low BUN/creatinine ratio can indicate a low protein diet, celiac disease, rhabdomyolysis, or cirrhosis of the liver.[103][104]
• Electrocardiogram (EKG or ECG): measures electrical activity of the heart. It can be used to detect various disorders such as hyperkalemia.[105]
• Electroencephalogram (EEG): measures the electrical activity of the brain. It can be used to detect abnormalities such as those associated with pituitary tumors.[106]
• Thyroid screen: test used to assess thyroid functioning by checking levels of thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3).[107]

Differential diagnoses

Main article: Anorexia nervosa (differential diagnoses)

A variety of medical and psychological conditions have been misdiagnosed as anorexia nervosa; in some cases the correct diagnosis was not made for more than ten years.

The distinction between the diagnosis of anorexia nervosa, bulimia nervosa and eating disorder not otherwise specified (EDNOS) is often difficult to make as there is considerable overlap between people diagnosed with these conditions. Seemingly minor changes in people's overall behavior or attitude can change a diagnosis from anorexia: binge-eating type to bulimia nervosa. A main factor differentiating binge-purge anorexia from bulimia is the gap in physical weight. Someone with bulimia nervosa is ordinarily at a healthy weight, or slightly overweight. Someone with binge-purge anorexia is commonly underweight.[108] People with the binge-purging subtype of AN may be significantly underweight and typically do not binge-eat large amounts of food, yet they purge the small amount of food they eat.[108] In contrast, those with bulimia nervosa tend to be at normal weight or overweight and binge large amounts of food.[108] It is not unusual for a person with an eating disorder to "move through" various diagnoses as their behavior and beliefs change over time.[47]

Treatment

There is no conclusive evidence that any particular treatment for anorexia nervosa works better than others; however, there is enough evidence to suggest that early intervention and treatment are more effective.[109] Treatment for anorexia nervosa tries to address three main areas.

• Restoring the person to a healthy weight;
• Treating the psychological disorders related to the illness;
• Reducing or eliminating behaviours or thoughts that originally led to the disordered eating.[110]

Although restoring the person's weight is the primary task at hand, optimal treatment also includes and monitors behavioral change in the individual as well.[111] There is some evidence that hospitalisation might adversely affect long term outcome.[112]

Psychotherapy for individuals with AN is challenging as they may value being thin and may seek to maintain control and resist change.[113] Some studies demonstrate that family based therapy in adolescents with AN is superior to individual therapy.[114] Due to the nature of the condition, treatment of people with AN can be difficult because they are afraid of gaining weight. Initially developing a desire to change is important.[115]

Diet

Diet is the most essential factor to work on in people with anorexia nervosa, and must be tailored to each person's needs. Food variety is important when establishing meal plans as well as foods that are higher in energy density.[116] People must consume adequate calories, starting slowly, and increasing at a measured pace.[25] Evidence of a role for zinc supplementation during refeeding is unclear.[14]

Therapy

Family-based treatment (FBT) has been shown to be more successful than individual therapy for adolescents with AN.[8][117] Various forms of family-based treatment have been proven to work in the treatment of adolescent AN including conjoint family therapy (CFT), in which the parents and child are seen together by the same therapist, and separated family therapy (SFT) in which the parents and child attend therapy separately with different therapists.[8] Proponents of family therapy for adolescents with AN assert that it is important to include parents in the adolescent's treatment.[8]

A four- to five-year follow up study of the Maudsley family therapy, an evidence-based manualized model, showed full recovery at rates up to 90%.[118] Although this model is recommended by the NIMH,[119] critics claim that it has the potential to create power struggles in an intimate relationship and may disrupt equal partnerships.

There is tentative evidence that family therapy is as effective as treatment as usual and it is unclear if family therapy is more effective than educational interventions.[120]

Cognitive behavioral therapy (CBT) is useful in adolescents and adults with anorexia nervosa;[121] acceptance and commitment therapy is a type of CBT, which has shown promise in the treatment of AN.[122] Cognitive remediation therapy (CRT) is used in treating anorexia nervosa.[123]

Medication

Pharmaceuticals have limited benefit for anorexia itself.[124][91] There is a lack of good information from which to make recommendations concerning the effectiveness of antidepressants in treating anorexia.[125]

Admission to hospital

AN has a high mortality[126] and patients admitted in a severely ill state to medical units are at particularly high risk. Diagnosis can be challenging, risk assessment may not be performed accurately, consent and the need for compulsion may not be assessed appropriately, refeeding syndrome may be missed or poorly treated and the behavioural and family problems in AN may be missed or poorly managed.[127] The MARSIPAN guidelines recommend that medical and psychiatric experts work together in managing severely ill people with AN.[128]

Nutrition

The rate of refeeding can be difficult to establish, because the fear of refeeding syndrome (RFS) can lead to underfeeding. It is thought that RFS, with falling phosphate and potassium levels, is more likely to occur when BMI is very low, and when medical comorbidities such as infection or cardiac failure, are present. In those circumstances, it is recommended to start refeeding slowly but to build up rapidly as long as RFS does not occur. Recommendations on energy requirements vary, from 5–10 kcal/kg/day in the most medically compromised patients, who appear to have the highest risk of RFS, to 1900 kcal/day.[129][130]

Prognosis

Deaths due to eating disorders per million persons in 2012

  0-1

  1-2

  2-3

  3-4

  4-25

AN has the highest mortality rate of any psychological disorder.[8] The mortality rate is 11 to 12 times greater than in the general population, and the suicide risk is 56 times higher.[20] Half of women with AN achieve a full recovery, while an additional 20–30% may partially recover.[8][20] Not all people with anorexia recover completely: about 20% develop anorexia nervosa as a chronic disorder.[109] If anorexia nervosa is not treated, serious complications such as heart conditions[18] and kidney failure can arise and eventually lead to death.[131] The average number of years from onset to remission of AN is seven for women and three for men. After ten to fifteen years, 70% of people no longer meet the diagnostic criteria, but many still continue to have eating-related problems.[132]

Alexithymia influences treatment outcome.[124] Recovery is also viewed on a spectrum rather than black and white. According to the Morgan-Russell criteria, individuals can have a good, intermediate, or poor outcome. Even when a person is classified as having a "good" outcome, weight only has to be within 15% of average, and normal menstruation must be present in females. The good outcome also excludes psychological health. Recovery for people with anorexia nervosa is undeniably positive, but recovery does not mean a return to normal.

Complications

Anorexia nervosa can have serious implications if its duration and severity are significant and if onset occurs before the completion of growth, pubertal maturation, or the attainment of peak bone mass. Complications specific to adolescents and children with anorexia nervosa can include the following: Growth retardation may occur, as height gain may slow and can stop completely with severe weight loss or chronic malnutrition. In such cases, provided that growth potential is preserved, height increase can resume and reach full potential after normal intake is resumed. Height potential is normally preserved if the duration and severity of illness are not significant or if the illness is accompanied by delayed bone age (especially prior to a bone age of approximately 15 years), as hypogonadism may partially counteract the effects of undernutrition on height by allowing for a longer duration of growth compared to controls. Appropriate early treatment can preserve height potential, and may even help to increase it in some post-anorexic subjects, due to factors such as long-term reduced estrogen-producing adipose tissue levels compared to premorbid levels. In some cases, especially where onset is before puberty, complications such as stunted growth and pubertal delay are usually reversible.[133]

Anorexia nervosa causes alterations in the female reproductive system; significant weight loss, as well as psychological stress and intense exercise, typically results in a cessation of menstruation in women who are past puberty. In patients with anorexia nervosa, there is a reduction of the secretion of gonadotropin releasing hormone in the central nervous system, preventing ovulation.[134] Anorexia nervosa can also result in pubertal delay or arrest. Both height gain and pubertal development are dependent on the release of growth hormone and gonadotropins (LH and FSH) from the pituitary gland. Suppression of gonadotropins in people with anorexia nervosa has been documented.[135] Typically, growth hormone (GH) levels are high, but levels of IGF-1, the downstream hormone that should be released in response to GH are low; this indicates a state of “resistance” to GH due to chronic starvation.[136] IGF-1 is necessary for bone formation, and decreased levels in anorexia nervosa contribute to a loss of bone density and potentially contribute to osteopenia or osteoporosis.[136] Anorexia nervosa can also result in reduction of peak bone mass. Buildup of bone is greatest during adolescence, and if onset of anorexia nervosa occurs during this time and stalls puberty, low bone mass may be permanent.[137]

Hepatic steatosis, or fatty infiltration of the liver, can also occur, and is an indicator of malnutrition in children.[138] Neurological disorders that may occur as complications include seizures and tremors. Wernicke encephalopathy, which results from vitamin B1 deficiency, has been reported in patients who are extremely malnourished; symptoms include confusion, problems with the muscles responsible for eye movements and abnormalities in walking gait.

The most common gastrointestinal complications of anorexia nervosa are delayed stomach emptying and constipation, but also include elevated liver function tests, diarrhea, acute pancreatitis, heartburn, difficulty swallowing, and, rarely, superior mesenteric artery syndrome.[139] Delayed stomach emptying, or gastroparesis, often develops following food restriction and weight loss; the most common symptom is bloating with gas and abdominal distension, and often occurs after eating. Other symptoms of gastroparesis include early satiety, fullness, nausea, and vomiting. The symptoms may inhibit efforts at eating and recovery, but can be managed by limiting high-fiber foods, using liquid nutritional supplements, or using metoclopramide to increase emptying of food from the stomach.[139] Gastroparesis generally resolves when weight is regained.

Cardiac complications

Anorexia nervosa increases the risk of sudden cardiac death, though the precise cause is unknown. Cardiac complications include structural and functional changes to the heart.[140] Some of these cardiovascular changes are mild and are reversible with treatment, while others may be life-threatening. Cardiac complications can include arrhythmias, abnormally slow heart beat, low blood pressure, decreased size of the heart muscle, reduced heart volume, mitral valve prolapse, myocardial fibrosis, and pericardial effusion.[140]

Abnormalities in conduction and repolarization of the heart that can result from anorexia nervosa include QT prolongation, increased QT dispersion, conduction delays, and junctional escape rhythms.[140] Electrolyte abnormalities, particularly hypokalemia and hypomagnesemia, can cause anomalies in the electrical activity of the heart, and result in life-threatening arrhythmias. Hypokalemia most commonly results in anorexic patients when restricting is accompanied by purging (induced vomiting or laxative use). Hypotension (low blood pressure) is common, and symptoms include fatigue and weakness. Orthostatic hypotension, a marked decrease in blood pressure when standing from a supine position, may also occur. Symptoms include lightheadedness upon standing, weakness, and cognitive impairment, and may result in fainting or near-fainting.[140] Orthostasis in anorexia nervosa indicates worsening cardiac function and may indicate a need for hospitalization.[140] Hypotension and orthostasis generally resolve upon recovery to a normal weight. The weight loss in anorexia nervosa also causes atrophy of cardiac muscle. This leads to decreased ability to pump blood, a reduction in the ability to sustain exercise, a diminished ability to increase blood pressure in response to exercise, and a subjective feeling of fatigue.[141]

Some individuals may also have a decrease in cardiac contractility. Cardiac complications can be life-threatening, but the heart muscle generally improves with weight gain, and the heart normalizes in size over weeks to months, with recovery.[141] Atrophy of the heart muscle is a marker of the severity of the disease, and while it is reversible with treatment and refeeding, it is possible that it may cause permanent, microscopic changes to the heart muscle that increase the risk of sudden cardiac death.[140] Individuals with anorexia nervosa may experience chest pain or palpitations; these can be a result of mitral valve prolapse. Mitral valve prolapse occurs because the size of the heart muscle decreases while the tissue of the mitral valve remains the same size. Studies have shown rates of mitral valve prolapse of around 20 percent in those with anorexia nervosa, while the rate in the general population is estimated at 2–4 percent.[142] It has been suggested that there is an association between mitral valve prolapse and sudden cardiac death, but it has not been proven to be causative, either in patients with anorexia nervosa or in the general population.[140]

Relapse

Rates of relapse after treatment range from 9–52% with many studies reporting a relapse rate of at least 25%.[91] Relapse occurs in approximately a third of people in hospital, and is greatest in the first six to eighteen months after release from an institution.[143]

Epidemiology

Anorexia is estimated to occur in 0.9% to 4.3% of women and 0.2% to 0.3% of men in Western countries at some point in their life.[15] About 0.4% of young females are affected in a given year and it is estimated to occur three to ten times less commonly in males.[3][15][143] Rates in most of the developing world are unclear.[3] Often it begins during the teen years or young adulthood.[1]

The lifetime rate of atypical anorexia nervosa, a form of ED-NOS in which the person loses a significant amount of weight and is at risk for serious medical complications despite having a higher body-mass index, is much higher, at 5–12%.[144]

While anorexia became more commonly diagnosed during the 20th century it is unclear if this was due to an increase in its frequency or simply better diagnosis.[2] Most studies show that since at least 1970 the incidence of AN in adult women is fairly constant, while there is some indication that the incidence may have been increasing for girls aged between 14 and 20.[15] According to researcher Ben Radford who wrote in Skeptical Inquirer "I found many examples of flawed, misleading, and sometimes completely wrong information and data being copied and widely disseminated among eating disorder organizations and educators without anyone bothering to consult the original research to verify its accuracy". Radford states that misleading statistics and data have been ignored by organizations like the National Eating Disorder Association who has not released data for "incidence of anorexia from 1984–2017" he states that each agency continues to report incorrect numbers assuming that someone else has checked the accuracy.[145]

Underrepresentation

Eating disorders are less reported in preindustrial, non-westernized countries than in Western countries. In Africa, not including South Africa, the only data presenting information about eating disorders occurs in case reports and isolated studies, not studies investigating prevalence. Data shows in research that in westernized civilizations, ethnic minorities have very similar rates of eating disorders, contrary to the belief that eating disorders predominantly occur in white people.

Men (and women) who might otherwise be diagnosed with anorexia may not meet the DSM IV criteria for BMI since they have muscle weight, but have very little fat.[146] Male and female athletes are often overlooked as anorexic.[146] Research emphasizes the importance to take athletes' diet, weight and symptoms into account when diagnosing anorexia, instead of just looking at weight and BMI. For athletes, ritualized activities such as weigh-ins place emphasis on weight, which may promote the development of eating disorders among them. While women use diet pills, which is an indicator of unhealthy behavior and an eating disorder, men use steroids, which contextualizes the beauty ideals for genders.[48] In a Canadian study, 4% of boys in grade nine used anabolic steroids.[48] Anorexic men are sometimes referred to as manorexic.[147]

History

Main article: History of anorexia nervosa

Two images of an anorexic woman published in 1900 in "Nouvelle Iconographie de la Salpêtrière". The case was titled "Un cas d'anorexie hysterique" (A case of hysteric anorexia).

The term "anorexia nervosa" was coined in 1873 by Sir William Gull, one of Queen Victoria's personal physicians.[17] The history of anorexia nervosa begins with descriptions of religious fasting dating from the Hellenistic era[148] and continuing into the medieval period. The medieval practice of self-starvation by women, including some young women, in the name of religious piety and purity also concerns anorexia nervosa; it is sometimes referred to as anorexia mirabilis.[149][150]

The earliest medical descriptions of anorexic illnesses are generally credited to English physician Richard Morton in 1689.[148] Case descriptions fitting anorexic illnesses continued throughout the 17th, 18th and 19th centuries.[151]

In the late 19th century anorexia nervosa became widely accepted by the medical profession as a recognized condition. In 1873, Sir William Gull, one of Queen Victoria's personal physicians, published a seminal paper which coined the term "anorexia nervosa" and provided a number of detailed case descriptions and treatments.[151] In the same year, French physician Ernest-Charles Lasègue similarly published details of a number of cases in a paper entitled De l'Anorexie hystérique.[152]

Awareness of the condition was largely limited to the medical profession until the latter part of the 20th century, when German-American psychoanalyst Hilde Bruch published The Golden Cage: the Enigma of Anorexia Nervosa in 1978. Despite major advances in neuroscience,[153] Bruch's theories tend to dominate popular thinking. A further important event was the death of the popular singer and drummer Karen Carpenter in 1983, which prompted widespread ongoing media coverage of eating disorders.[154]

Etymology

The term is of Greek origin: an- (ἀν-, prefix denoting negation) and orexis (ὄρεξις, "appetite"), translating literally to a nervous loss of appetite.[155]

See also

• Eating recovery
• Idée fixe
• Inedia
• List of people with anorexia nervosa
• National Association of Anorexia Nervosa and Associated Disorders
• Orthorexia nervosa
• Pro-ana

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Further reading

• Bailey AP, Parker AG, Colautti LA, Hart LM, Liu P, Hetrick SE (2014). "Mapping the evidence for the prevention and treatment of eating disorders in young people". Journal of Eating Disorders. 2 (1): 5. doi:10.1186/2050-2974-2-5. PMC 4081733. PMID 24999427.
• Coelho GM, Gomes AI, Ribeiro BG, Soares E (2014). "Prevention of eating disorders in female athletes". Open Access Journal of Sports Medicine. 5: 105–13. doi:10.2147/OAJSM.S36528. PMC 4026548. PMID 24891817.
• Luca A, Luca M, Calandra C (February 2015). "Eating Disorders in Late-life". Aging and Disease. 6 (1): 48–55. doi:10.14336/AD.2014.0124. PMC 4306473. PMID 25657852.

External links

• National Association of Anorexia Nervosa and Associated Disorders
• Society of Clinical Psychology—Anorexia

Classification	D ICD-10: F50.0-F50.1 ICD-9-CM: 307.1 OMIM: 606788 MeSH: D000856 DiseasesDB: 749
External resources	MedlinePlus: 000362 eMedicine: emerg/34 med/144 Patient UK: Anorexia nervosa