Adamalysin
Adamalysin (EC 3.4.24.46, Crotalus adamanteus metalloendopeptidase, proteinase I and II, Crotalus adamanteus venom proteinase II, adamalysin II) is an enzyme.[1] This enzyme catalyses the following chemical reaction
- Cleavage of Phe1-Val, His5-Leu, His10-Leu, Ala14-Leu, Leu15-Tyr, and Tyr16-Leu of insulin B chain
| Adamalysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.46 | ||||||||
| CAS number | 74812-51-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is present in the venom of the eastern diamondback rattlesnake (Crotalus adamanteus).
See also
- A disintegrin and metalloproteinase
References
- Kurecki T, Laskowski M, Kress LF (November 1978). "Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human alpha 1-proteinase inhibitor". The Journal of Biological Chemistry. 253 (22): 8340–5. PMID 309470.
External links
- Adamalysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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