ADAMTS-4 endopeptidase

ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan
ADAMTS-4 endopeptidase
Identifiers
EC number3.4.24.82
CAS number147172-61-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme belongs to the peptidase family M12.

References

  1. Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD (May 2002). "ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain". The Journal of Biological Chemistry. 277 (18): 16059–66. doi:10.1074/jbc.M108607200. PMID 11854269.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.