2-Hydroxyacylsphingosine 1-beta-galactosyltransferase
In enzymology, a 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (EC 2.4.1.45) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + 2-(2-hydroxyacyl)sphingosine UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine
| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.45 | ||||||||
| CAS number | 37277-54-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are UDP-galactose and 2-(2-hydroxyacyl)sphingosine, whereas its two products are UDP and 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase. Other names in common use include galactoceramide synthase[1], uridine diphosphogalactose-2-hydroxyacylsphingosine, galactosyltransferase, UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, and UDP-galactose:2-2-hydroxyacylsphingosine galactosyltransferase.
References
- Shayman, James (2006). "Glucosylceramide and Galactosylceramide Synthase". Sphingolipid Biology. Tokyon: Springer. pp. 83–94. doi:10.1007/4-431-34200-1_6. ISBN 978-4-431-34200-7.
- Basu S, Schultz AM, Basu M, Roseman S (1971). "Enzymatic synthesis of galactocerebroside by a galactosyltransferase from embryonic chicken brain". J. Biol. Chem. 246 (13): 4272–9. PMID 5090043.
- Morell P, Radin NS (1969). "Synthesis of cerebroside by brain from uridine diphosphate galactose and ceramide containing hydroxy fatty acid". Biochemistry. 8 (2): 506–12. doi:10.1021/bi00830a008. PMID 5793706.