Cationic amino acid transporter 4

Cationic amino acid transporter 4 is a protein that in humans is encoded by the SLC7A4 gene.[5][6][7]

SLC7A4
Identifiers
Aliases	SLC7A4, CAT-4, CAT4, HCAT3, VH, solute carrier family 7 member 4
External IDs	OMIM: 603752 MGI: 2146512 HomoloGene: 20883 GeneCards: SLC7A4
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.21 Start 21,028,718 bp[1] End 21,032,840 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A3 Start 17,572,018 bp[2] End 17,583,214 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • basic amino acid transmembrane transporter activity • GO:0022891 transmembrane transporter activity • amino acid transmembrane transporter activity Cellular component • integral component of membrane • membrane Biological process • cellular amino acid metabolic process • amino acid transport • basic amino acid transmembrane transport • transmembrane transport • amino acid transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6545	224022
Ensembl	ENSG00000099960	ENSMUSG00000022756
UniProt	O43246	Q8BLQ7
RefSeq (mRNA)	NM_004173	NM_144852 NM_001359891 NM_001359892 NM_001359893
RefSeq (protein)	NP_004164	NP_659101 NP_001346820 NP_001346821 NP_001346822
Location (UCSC)	Chr 22: 21.03 – 21.03 Mb	Chr 16: 17.57 – 17.58 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• SLC7A4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000099960 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022756 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sperandeo MP, Borsani G, Incerti B, Zollo M, Rossi E, Zuffardi O, Castaldo P, Taglialatela M, Andria G, Sebastio G (Aug 1998). "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome". Genomics. 49 (2): 230–6. doi:10.1006/geno.1998.5252. PMID 9598310.
6. Hammermann R, Brunn G, Racke K (Oct 2001). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4". Amino Acids. 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818.
7. "Entrez Gene: SLC7A4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4".

Further reading

• Muñoz L, Lasa A, Carricondo MT, et al. (2007). "Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia". Cytometry Part B. 72 (2): 96–102. doi:10.1002/cyto.b.20149. PMID 17051526.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wolf S, Janzen A, Vékony N, et al. (2002). "Expression of solute carrier 7A4 (SLC7A4) in the plasma membrane is not sufficient to mediate amino acid transport activity". Biochem. J. 364 (Pt 3): 767–75. doi:10.1042/BJ20020084. PMC 1222626. PMID 12049641.
• Neshat MN, Goodglick L, Lim K, Braun J (2000). "Mapping the B cell superantigen binding site for HIV-1 gp120 on a V(H)3 Ig". Int. Immunol. 12 (3): 305–12. doi:10.1093/intimm/12.3.305. PMID 10700465.
• Fischer M, Küppers R (1998). "Human IgA- and IgM-secreting intestinal plasma cells carry heavily mutated VH region genes". Eur. J. Immunol. 28 (9): 2971–7. doi:10.1002/(SICI)1521-4141(199809)28:09<2971::AID-IMMU2971>3.0.CO;2-3. PMID 9754584.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.