Glucose-6-phosphate exchanger SLC37A1

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.[5] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.[6]

SLC37A1
Identifiers
Aliases	SLC37A1, G3PP, solute carrier family 37 member 1
External IDs	OMIM: 608094 MGI: 2446181 HomoloGene: 70486 GeneCards: SLC37A1
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 42,496,008 bp[1] End 42,581,440 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 31,286,792 bp[2] End 31,350,739 bp[2]
Gene ontology Molecular function • transporter activity • antiporter activity • glucose 6-phosphate:inorganic phosphate antiporter activity • GO:0022891 transmembrane transporter activity Cellular component • integral component of endoplasmic reticulum membrane • membrane • endoplasmic reticulum • integral component of membrane • endoplasmic reticulum membrane Biological process • phosphate ion transmembrane transport • carbohydrate transport • transmembrane transport • glucose-6-phosphate transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54020	224674
Ensembl	ENSG00000160190	ENSMUSG00000024036
UniProt	P57057	Q8R070
RefSeq (mRNA)	NM_018964 NM_001320537	NM_001242427 NM_153062
RefSeq (protein)	NP_001307466 NP_061837	NP_001229356 NP_694702
Location (UCSC)	Chr 21: 42.5 – 42.58 Mb	Chr 17: 31.29 – 31.35 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,[7] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000160190 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024036 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
6. "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
7. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLoS One. 6 (9): e23157. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
8. Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17: 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

Further reading

• Bartoloni L, Antonarakis SE (February 2004). "The human sugar-phosphate/phosphate exchanger family SLC37". Pflügers Archiv. 447 (5): 780–3. doi:10.1007/s00424-003-1105-0. PMID 12811562.