Chloride potassium symporter
The potassium chloride symporter is a membrane transport protein that is present in the S3-segment of the renal proximal tubule[1] and in the neuron.[2] It functions in renal chloride reabsorption to transport chloride across the basolateral membrane.[1] The concentrations of K+ and Cl− ions are high inside the cell due to the activities of Na+-K+ pump and NKCC cotransporter, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and Cl− from the cell.
They can lower intracellular chloride concentrations below the electrochemical equilibrium potential.[2]
They are of solute carrier family 12.
Types
Types of chloride potassium symporter are:
Each is encoded by a separate gene.
The preceding symporters are other types of ion pumps. Member 3, for instance, is the sodium-chloride symporter.
References
- Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 780
- "Entrez Gene: SLC12A5 solute carrier family 12, (potassium-chloride transporter) member 5". Retrieved 28 August 2013.
F-, V-, and A-type ATPase (3.A.2) |
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P-type ATPase (3.A.3) | |||||||
see also ATPase disorders |
Proteins: carrier proteins | |
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Fatty acid | |
Hormone | |
Metal/element | |
Vitamin |
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Pigment | |
Other |
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see also solute carrier disorders |
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see also disorders |
Membrane transport protein: neurotransmitter transporters (TC 2.A.1.2) | |
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Vesicular |
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Other |