Putative sodium-coupled neutral amino acid transporter 10

Putative sodium-coupled neutral amino acid transporter 10, also known as solute carrier family 38 member 10, is a protein that in humans is encoded by the SLC38A10 gene.[5]

SLC38A10
Identifiers
AliasesSLC38A10, PP1744, solute carrier family 38 member 10
External IDsOMIM: 616525 MGI: 1919305 HomoloGene: 41556 GeneCards: SLC38A10
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q25.3Start81,244,811 bp[1]
End81,295,547 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

124565

72055

Ensembl

ENSG00000157637

ENSMUSG00000061306

UniProt

Q9HBR0

Q5I012

RefSeq (mRNA)

NM_001037984
NM_138570

RefSeq (protein)

NP_001033073
NP_612637

Location (UCSC)Chr 17: 81.24 – 81.3 MbChr 11: 120.1 – 120.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Model organisms

Model organisms have been used in the study of SLC38A10 function. A conditional knockout mouse line, called Slc38a10tm1a(EUCOMM)Wtsi[14][15] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[12][19] Twenty four tests were carried out on mutant mice and four significant abnormalities were observed.[12] Homozygous animals of both sex had decreased body weights, and DEXA analysis showed that this correlated with decreased bone mineral content and decreased body length. Indirect calorimetry analysis showed that males displayed increased oxygen consumption and energy expenditure, while clinical chemistry tests found that females had decreased circulating amylase levels and males had hypoalbuminemia and increased circulating creatinine levels.[12]

Cancer

A SLC38A family member has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy.[20] For this reason, SLC38A is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.[20]

References
  1. GRCh38: Ensembl release 89: ENSG00000157637 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000061306 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: solute carrier family 38, member 10". Retrieved 2011-08-30.
  6. "Body weight data for Slc38a10". Wellcome Trust Sanger Institute.
  7. "Indirect calorimetry data for Slc38a10". Wellcome Trust Sanger Institute.
  8. "DEXA data for Slc38a10". Wellcome Trust Sanger Institute.
  9. "Clinical chemistry data for Slc38a10". Wellcome Trust Sanger Institute.
  10. "Salmonella infection data for Slc38a10". Wellcome Trust Sanger Institute.
  11. "Citrobacter infection data for Slc38a10". Wellcome Trust Sanger Institute.
  12. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  13. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  14. "International Knockout Mouse Consortium".
  15. "Mouse Genome Informatics".
  16. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  17. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  18. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  19. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
  20. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.

Further reading


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