Asc-type amino acid transporter 1

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.[5][6][7]

SLC7A10
Identifiers
Aliases	SLC7A10, HASC-1, asc-1, ASC1, solute carrier family 7 member 10
External IDs	OMIM: 607959 MGI: 1858261 HomoloGene: 56767 GeneCards: SLC7A10
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.11 Start 33,208,664 bp[1] End 33,225,850 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B2|7 21.13 cM Start 35,186,385 bp[2] End 35,201,114 bp[2]
Gene ontology Molecular function • antiporter activity • L-serine transmembrane transporter activity • neutral amino acid transmembrane transporter activity • GO:0022891 transmembrane transporter activity • L-amino acid transmembrane transporter activity Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane Biological process • leukocyte migration • neutral amino acid transport • D-alanine transport • amino acid transport • D-serine transport • L-serine transport • transmembrane transport • L-alpha-amino acid transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56301	53896
Ensembl	ENSG00000130876	ENSMUSG00000030495
UniProt	Q9NS82	P63115
RefSeq (mRNA)	NM_019849	NM_017394
RefSeq (protein)	NP_062823	NP_059090
Location (UCSC)	Chr 19: 33.21 – 33.23 Mb	Chr 7: 35.19 – 35.2 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Heterodimeric amino acid transporter

References

1. GRCh38: Ensembl release 89: ENSG00000130876 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030495 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 10".
6. Fukasawa Y; Segawa H; Kim JY; Chairoungdua A; Kim DK; Matsuo H; Cha SH; Endou H; Kanai Y (March 2000). "Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids". J. Biol. Chem. 275 (13): 9690–8. doi:10.1074/jbc.275.13.9690. PMID 10734121.
7. Nakauchi J; Matsuo H; Kim DK; Goto A; Chairoungdua A; Cha SH; Inatomi J; Shiokawa Y; Yamaguchi K; Saito I; Endou H; Kanai Y (June 2000). "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity". Neurosci. Lett. 287 (3): 231–5. doi:10.1016/S0304-3940(00)01169-1. PMID 10863037.

Further reading

• Leclerc D, Wu Q, Ellis JR, et al. (2001). "Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?". Mol. Genet. Metab. 73 (4): 333–9. doi:10.1006/mgme.2001.3209. PMID 11509015.
• Imielinski M, Baldassano RN, Griffiths A, et al. (2009). "Common variants at five new loci associated with early-onset inflammatory bowel disease". Nat. Genet. 41 (12): 1335–40. doi:10.1038/ng.489. PMC 3267927. PMID 19915574.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pineda M, Font M, Bassi MT, et al. (2004). "The amino acid transporter asc-1 is not involved in cystinuria". Kidney Int. 66 (4): 1453–64. doi:10.1111/j.1523-1755.2004.00908.x. PMID 15458438.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184.
• Bröer S (January 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiol. Rev. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
• Xu D; Hemler ME (2005). "Metabolic activation-related CD147-CD98 complex". Mol. Cell. Proteomics. 4 (8): 1061–71. doi:10.1074/mcp.M400207-MCP200. PMC 1351277. PMID 15901826.