Valsartan/hydrochlorothiazide

Valsartan/hydrochlorothiazide, sold under the trade name Co-Diovan among others, is an medication used to treat high blood pressure when valsartan is not sufficient.[1] It is a combination of valsartan, an angiotensin receptor blocker with hydrochlorothiazide, a diuretic.[2] It is taken by mouth.[2]

Valsartan/hydrochlorothiazide
Combination of
ValsartanAngiotensin II receptor antagonist
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesCo-vasotec, Diovan HCT, Co-Diovan, others
AHFS/Drugs.comFDA Professional Drug Information
MedlinePlusa611032
License data
Pregnancy
category
  • US: D (Evidence of risk)
    Routes of
    administration    		By mouth
    ATC code
    Legal status
    Legal status
    Identifiers
    PubChem CID
    KEGG
    CompTox Dashboard (EPA)
      (verify)

    Common side effects include dizziness and headaches.[2] Serious side effects may include allergic reactions, electrolyte abnormalities, and glaucoma.[3] Use in pregnancy is not recommended.[3]

    The combination was approved for medical use in the United States in 1998.[2] It is available as a generic medication.[1] A month supply in the United Kingdom costs the NHS about 1.85 as of 2019.[1] In the United States the wholesale cost of this amount is about US$4.40.[4] In 2017, it was the 133rd most commonly prescribed medication in the United States, with more than five million prescriptions.[5][6]

    References
    1. British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 179. ISBN 9780857113382.
    2. "Hydrochlorothiazide and valsartan Uses, Side Effects & Warnings". Drugs.com. Retrieved 10 March 2019.
    3. "Valsartan and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 10 March 2019.
    4. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
    5. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
    6. "Hydrochlorothiazide; Valsartan - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.


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