Delapril
Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15 mg and 30 mg tablets.[3]
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C26H32N2O5 |
| Molar mass | 452.551 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  | |
Mechanism
Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4]
gollark: *Can* you efficiently just convert carbon dioxide/water back into oxygen/carbon? I mean, the whole reason we do it the other way round is the fact that a lot of energy is released.
gollark: Or just keep them lying around, like in forests, but there are capacity limits.
gollark: I mean, plants turn carbon dioxide into... plant bits... which means you have to grow plants and then stockpile those plant bits somewhere without burning them.
gollark: Funnily enough, photovoltaic panels are actually more efficient at sunlight→energy conversion than plants.
gollark: I mean, probably not as many radioactive things being released, at least.
References
- Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–63. PMC 2293964. PMID 17703633.
- "Delapril". Drugs.com.
- "Delapril". cursoenarm.net. Retrieved 2016-08-28.
- "Delapril". Pubchem. U.S. National Library of Medicine. Retrieved 2016-08-28.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.