Ulp1 peptidase

Ulp1 peptidase (EC 3.4.22.68, Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-!Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3
Ulp1 peptidase
Identifiers
EC number3.4.22.68
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human.

References

  1. Lima CD, Rawlings ND, Woessner JF (2004). "Ulp1 endopeptidase". In Barrett AJ (ed.). Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1340–1344.
  2. Li SJ, Hochstrasser M (March 1999). "A new protease required for cell-cycle progression in yeast". Nature. 398 (6724): 246–51. doi:10.1038/18457. PMID 10094048.
  3. Taylor DL, Ho JC, Oliver A, Watts FZ (March 2002). "Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease". Journal of Cell Science. 115 (Pt 6): 1113–22. PMID 11884512.
  4. Li SJ, Hochstrasser M (March 2003). "The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity". The Journal of Cell Biology. 160 (7): 1069–81. doi:10.1083/jcb.200212052. PMC 2172760. PMID 12654900.
  5. Ihara M, Koyama H, Uchimura Y, Saitoh H, Kikuchi A (June 2007). "Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth". The Journal of Biological Chemistry. 282 (22): 16465–75. doi:10.1074/jbc.M610723200. PMID 17428805.
  6. Mukhopadhyay D, Dasso M (June 2007). "Modification in reverse: the SUMO proteases". Trends in Biochemical Sciences. 32 (6): 286–95. doi:10.1016/j.tibs.2007.05.002. PMID 17499995.
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