Tetrahydroxynaphthalene reductase
In enzymology, a tetrahydroxynaphthalene reductase (EC 1.1.1.252) is an enzyme that catalyzes the chemical reaction
- scytalone + NADP+ 1,3,6,8-tetrahydroxynaphthalene + NADPH + H+
tetrahydroxynaphthalene reductase | |||||||||
---|---|---|---|---|---|---|---|---|---|
Identifiers | |||||||||
EC number | 1.1.1.252 | ||||||||
CAS number | 153702-05-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
|
Thus, the two substrates of this enzyme are scytalone and NADP+, whereas its 3 products are 1,3,6,8-tetrahydroxynaphthalene, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is scytalone:NADP+ Delta5-oxidoreductase.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1DOH, 1G0N, and 1G0O.
gollark: You know how every paste gets some reasonably large amount of views after it's made? I'm pretty sure that's them being archived somewhere.
gollark: I think there are even printed copies somewhere ingame.
gollark: I'm sure it's been backuped in a lot of places now.
gollark: I can't "delete potatos". How would that even work?
gollark: ...
References
- Wheeler MH; Greenblatt GA (1988). "The inhibition of melanin biosynthetic reactions in Pyricularia oryzae by compounds that prevent rice blast disease". Exp. Mycol. 12 (2): 151–160. doi:10.1016/0147-5975(88)90004-7.
- Vidal-Cros A, Viviani F, Labesse G, Boccara M, Gaudry M (1994). "Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing". Eur. J. Biochem. 219 (3): 985–92. doi:10.1111/j.1432-1033.1994.tb18581.x. PMID 8112349.
- Thompson JE, Basarab GS, Andersson A, Lindqvist Y, Jordan DB (1997). "Trihydroxynaphthalene reductase from Magnaporthe grisea: realization of an active center inhibitor and elucidation of the kinetic mechanism". Biochemistry. 36 (7): 1852–60. doi:10.1021/bi962355u. PMID 9048570.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.