Temoporfin

Temoporfin (INN) is a photosensitizer (based on chlorin) used in photodynamic therapy for the treatment of squamous cell carcinoma of the head and neck[1] .[2] It is marketed in the European Union under the brand name Foscan. The U.S. Food and Drug Administration (FDA) declined to approve Foscan in 2000. The EU approved its use in June 2001.[3]

Temoporfin
Clinical data
AHFS/Drugs.comInternational Drug Names
License data
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
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ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.152.970
Chemical and physical data
FormulaC44H32N4O4
Molar mass680.764 g·mol−1
3D model (JSmol)
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Good results were obtained in 21 of 35 patients treated in Germany.[4]

It is photoactivated at 652 nm[5] i.e. by red light.

Patients can remain photosensitive for several weeks after treatment.[2]

Further reading
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gollark: <@94122472290394112> EXT vs Skynet:Skynet:* wildcard channel - allows listening to all system messages* API may be nicer to use, as you don't *need* to call skynet.listen anywhere - you do need to call EXT.run somewhere, in parallel or something* Skynet's backend (not the CC side) assigns each connected socket an ID, and tells you which IDs recevied messages. This is not much use.EXT:* messages only readable by people on same channel or server operator* somewhat more complete API - allows closing channels - Skynet can do this but the CC side doesn't handle it
gollark: Yeeep.
gollark: No, because the storage system just lets you pull out items by their name.
gollark: Modern plethora-based item systems just allow you to deposit and withdraw items by name, that doesn't make sense.

References
  1. Lorenz KJ, Maier H (April 2008). "[Squamous cell carcinoma of the head and neck. Photodynamic therapy with Foscan]". HNO (in German). 56 (4): 402–9. doi:10.1007/s00106-007-1573-1. PMID 17516041.
  2. O'Connor, Aisling E; Gallagher, William M; Byrne, Annette T (2009). "Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy. Photochemistry and Photobiology, Sep/Oct 2009". Photochemistry and Photobiology.
  3. HighBeam Foscan approval saves Scotia's skin.
  4. Johannes Lorenz, Kai; Maier, Heinz (2009). "Photodynamic therapy with meta-tetrahydroxyphenylchlorin (Foscan®) in the management of squamous cell carcinoma of the head and neck: experience with 35 patients". European Archives of Oto-Rhino-Laryngology. 266 (12): 1937–1944. doi:10.1007/s00405-009-0947-2. PMID 19290535.
  5. "Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy". Photochemistry and Photobiology. 2009.


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