Serine 3-dehydrogenase
In enzymology, a serine 3-dehydrogenase (EC 1.1.1.276) is an enzyme that catalyzes the chemical reaction
- L-serine + NADP+ 2-ammoniomalonate semialdehyde + NADPH + H+
| serine 3-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.1.276 | ||||||||
| CAS number | 9038-55-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are L-serine and NADP+, whereas its 3 products are 2-ammoniomalonate semialdehyde, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-serine:NADP+ 3-oxidoreductase.
References
- Fujisawa H, Nagata S, Chowdhury EK, Matsumoto M, Misono H (2002). "Cloning and sequencing of the serine dehydrogenase gene from Agrobacterium tumefaciens". Biosci. Biotechnol. Biochem. 66 (5): 1137–9. doi:10.1271/bbb.66.1137. PMID 12092831.
- Chowdhury EK, Higuchi K, Nagata S, Misono H (1997). "A novel NADP(+)-dependent serine dehydrogenase from Agrobacterium tumefaciens". Biosci. Biotechnol. Biochem. 61 (1): 152–7. doi:10.1271/bbb.61.152. PMID 9028042.
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