HDAC3

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.[5][6][7][8]

HDAC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHDAC3, HD3, RPD3, RPD3-2, histone deacetylase 3
External IDsOMIM: 605166 MGI: 1343091 HomoloGene: 48250 GeneCards: HDAC3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Bandn/aStart141,620,876 bp[1]
End141,636,870 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8841

15183

Ensembl

ENSG00000171720

ENSMUSG00000024454

UniProt

O15379

O88895

RefSeq (mRNA)

NM_003883

NM_010411

RefSeq (protein)

NP_003874
NP_001341968
NP_001341969
NP_001341970

n/a

Location (UCSC)Chr 5: 141.62 – 141.64 MbChr 18: 37.94 – 37.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Histones are highly alkaline proteins that package and order DNA into structural units called nucleosomes, which comprise the major protein component of chromatin. The posttranslational and enzymatically mediated lysine acetylation and deacetylation of histone tails changes the local chromatin structure through altering the electrostatic attraction between the negatively charged DNA backbone and histones. HDAC3 is a Class I member of the histone deacetylase superfamily (comprising four classes based on function and DNA sequence homology) that is recruited to enhancers to modulate both the epigenome and nearby gene expression. HDAC3 is found exclusively in the cell nucleus where it is the sole endogenous histone deacetylase biochemically purified in the nuclear-receptor corepressor complex containing NCOR and SMRT (NCOR2). Thus, HDAC3 unlike other HDACs, has a unique role in modulating the transcriptional activities of nuclear receptors.

Alternative functions

Histone deacetylases can be regulated by endogenous factors, dietary components, synthetic inhibitors and bacteria-derived signals. Studies in mice with a specific deletion of HDAC3 in intestinal epithelial cells (IECs) show a deregulated IEC's gene expression. In these deletion-mutant mice, loss of Paneth cells, impaired IEC function and alterations in intestinal composition of commensal bacteria were observed. These negative effects were not observed in germ-free mice, indicating that the effects of the deletion are only seen in the presence of intestinal microbial colonization. But the negative effects of HDAC3 deletion are not due to the presence of an altered microbiota because normal germ-free mice colonized with the altered microbiota did not show the negative effects seen in deletion mutants.

Although the precise mechanism and the specific signals are not known it is clear that HDAC3 interacts with derived signals of commensal bacteria of the gut microbiota. These interactions are responsible of calibrating epithelial cells responses necessary to establish a normal relationship between the host and the commensal as well as to maintain intestinal homeostasis.[9][10][11][12]

Model organisms

Model organisms have been used in the study of HDAC3 function. A conditional knockout mouse line, called Hdac3tm1a(EUCOMM)Wtsi[17][18] was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[19][20][21]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[15][22]

Twenty six tests were carried out on mutant mice and two significant abnormalities were observed.[15] No homozygous mutant embryos were identified during gestation, and in a separate study none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no significant abnormalities were observed in these animals.[15]

Interactions

HDAC3 has been shown to interact with:

gollark: --remind 2000m Test.
gollark: Wait, maybe not.
gollark: Very unfathomable.
gollark: --remind 1mo test????
gollark: That was planned but deemed unworkable.

See also

References
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Further reading

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