Proprioception

Proprioception (/ˌproʊprioʊˈsɛpʃən, -priə-/[1][2] PROH-pree-o-SEP-shən), also referred to as kinaesthesia (or kinesthesia), is the sense of self-movement and body position.[3] It is sometimes described as the "sixth sense".[4]

Proprioception is mediated by proprioceptors, mechanosensory neurons located within muscles, tendons, and joints.[5] There are multiple types of proprioceptors which are activated during distinct behaviors and encode distinct types of information: limb velocity and movement, load on a limb, and limb limits. Vertebrates and invertebrates have distinct but similar modes of encoding this information.

The central nervous system integrates proprioception and other sensory systems, such as vision and the vestibular system, to create an overall representation of body position, movement, and acceleration.

More recently proprioception has also been described in flowering land plants (angiosperms).[6][7]

System overview

In vertebrates, limb velocity and movement (muscle length and the rate of change) are encoded by one group of sensory neurons (Type Ia sensory fiber) and another type encode static muscle length (Group II neurons).[8] These two types of sensory neurons compose muscle spindles. There is a similar division of encoding in invertebrates; different subgroups of neurons of the Chordotonal organ[9] encode limb position and velocity.

To determine the load on a limb, vertebrates use sensory neurons in the Golgi tendon organs:[10] type Ib afferents. These proprioceptors are activated at given muscle forces, which indicate the resistance that muscle is experiencing. Similarly, invertebrates have a mechanism to determine limb load: the Campaniform sensilla.[11] These proprioceptors are active when a limb experiences resistance.

A third role for proprioceptors is to determine when a joint is at a specific position. In vertebrates, this is accomplished by Ruffini endings and Pacinian corpuscles. These proprioceptors are activated when the joint is at a threshold, usually at the extremes of joint position. Invertebrates use hair plates[12] to accomplish this; a row of bristles located along joints detect when the limb moves.

Reflexes

The sense of proprioception is ubiquitous across mobile animals and is essential for the motor coordination of the body. Proprioceptors can form reflex circuits with motor neurons to provide rapid feedback about body and limb position. These mechanosensory circuits are important for flexibly maintaining posture and balance, especially during locomotion. For example, consider the stretch reflex, in which stretch across a muscle is detected by a sensory receptor (e.g., muscle spindle, chordotonal neurons), which activates a motor neuron to induce muscle contraction and oppose the stretch. During locomotion, sensory neurons can reverse their activity when stretched, to promote rather than oppose movement.[13][14]

Conscious and non-conscious

In humans, a distinction is made between conscious proprioception and non-conscious proprioception:

  • Conscious proprioception is communicated by the dorsal column-medial lemniscus pathway to the cerebrum.[15]
  • Non-conscious proprioception is communicated primarily via the dorsal spinocerebellar tract[16] and ventral spinocerebellar tract,[17] to the cerebellum.
  • A non-conscious reaction is seen in the human proprioceptive reflex, or righting reflex—in the event that the body tilts in any direction, the person will cock their head back to level the eyes against the horizon.[18] This is seen even in infants as soon as they gain control of their neck muscles. This control comes from the cerebellum, the part of the brain affecting balance.

Mechanisms

Proprioception is mediated by mechanically sensitive proprioceptor neurons distributed throughout an animal's body. Most vertebrates possess three basic types of proprioceptors: muscle spindles, which are embedded in skeletal muscle fibers, Golgi tendon organs, which lie at the interface of muscles and tendons, and joint receptors, which are low-threshold mechanoreceptors embedded in joint capsules. Many invertebrates, such as insects, also possess three basic proprioceptor types with analogous functional properties: chordotonal neurons, campaniform sensilla, and hair plates.[3]

The initiation of proprioception is the activation of a proprioreceptor in the periphery.[19] The proprioceptive sense is believed to be composed of information from sensory neurons located in the inner ear (motion and orientation) and in the stretch receptors located in the muscles and the joint-supporting ligaments (stance). There are specific nerve receptors for this form of perception termed "proprioreceptors", just as there are specific receptors for pressure, light, temperature, sound, and other sensory experiences. Proprioreceptors are sometimes known as adequate stimuli receptors. TRPN, a member of the transient receptor potential family of ion channels, has been found to be responsible for proprioception in fruit flies,[20] nematode worms,[21] African clawed frogs,[22] and zebrafish.[23] PIEZO2, a nonselective cation channel, has been shown to underlie the mechanosensitivity of proprioceptors in mice.[24] The channel mediating human proprioceptive mechanosensation has yet to be discovered.

Proprioception of the head stems from the muscles innervated by the trigeminal nerve, where the GSA fibers pass without synapsing in the trigeminal ganglion (first-order sensory neuron), reaching the mesencephalic tract and the mesencephalic nucleus of trigeminal nerve.

Although it was known that finger kinesthesia relies on skin sensation, recent research has found that kinesthesia-based haptic perception relies strongly on the forces experienced during touch.[25] This research allows the creation of "virtual", illusory haptic shapes with different perceived qualities.[26]

Function

Stability

An important role for proprioception is to allow an animal to stabilize itself against perturbations. For instance, for a person to walk or stand upright, they must continuously monitor their posture and adjust muscle activity as needed to provide balance. Similarly, when walking on unfamiliar terrain or even tripping, the person must adjust the output of their muscles quickly based on estimated limb position and velocity. Proprioceptor reflex circuits are thought to play an important role to allow fast and unconscious execution of these behaviors, To make control of these behaviors efficient, proprioceptors are also thought to regulate reciprocal inhibition in muscles, leading to agonist-antagonist muscle pairs.

Planning and refining movements

When planning complex movements such as reaching or grooming, animals must consider the current position and velocity of their limb and use it to adjust dynamics to target a final position. If the animal's estimate of their limb's initial position is wrong, this can lead to a deficiency in the movement. Furthermore, proprioception is crucial in refining the movement if it deviates from the trajectory.

Development

In adult Drosophila, each proprioceptor class arises from a specific cell lineage (i.e. each chordotonal neuron is from the chordotonal neuron lineage, although multiple lineages give rise to sensory bristles). After the last cell division, proprioceptors send out axons toward the central nervous system and are guided by hormonal gradients to reach stereotyped synapses. [27] The mechanisms underlying axon guidance are similar across invertebrates and vertebrates.

In mammals with longer gestation periods, muscle spindles are fully formed at birth. Muscle spindles continue to grow throughout post-natal development as muscles grow. [28]

Clinical relevance

Impairment

Temporary loss or impairment of proprioception may happen periodically during growth, mostly during adolescence. Growth that might also influence this would be large increases or drops in bodyweight/size due to fluctuations of fat (liposuction, rapid fat loss or gain) and/or muscle content (bodybuilding, anabolic steroids, catabolisis/starvation). It can also occur in those that gain new levels of flexibility, stretching, and contortion. A limb's being in a new range of motion never experienced (or at least, not for a long time since youth perhaps) can disrupt one's sense of location of that limb. Possible experiences include suddenly feeling that feet or legs are missing from one's mental self-image; needing to look down at one's limbs to be sure they are still there; and falling down while walking, especially when attention is focused upon something other than the act of walking.

Proprioception is occasionally impaired spontaneously, especially when one is tired. Similar effects can be felt during the hypnagogic state of consciousness, during the onset of sleep. One's body may feel too large or too small, or parts of the body may feel distorted in size. Similar effects can sometimes occur during epilepsy or migraine auras. These effects are presumed to arise from abnormal stimulation of the part of the parietal cortex of the brain involved with integrating information from different parts of the body.[29]

Proprioceptive illusions can also be induced, such as the Pinocchio illusion.

The proprioceptive sense is often unnoticed because humans will adapt to a continuously present stimulus; this is called habituation, desensitization, or adaptation. The effect is that proprioceptive sensory impressions disappear, just as a scent can disappear over time. One practical advantage of this is that unnoticed actions or sensation continue in the background while an individual's attention can move to another concern. The Alexander Technique addresses these unconscious elements by bringing attention to them and practicing a new movement with focus on how it feels to move in the new way.

People who have a limb amputated may still have a confused sense of that limb's existence on their body, known as phantom limb syndrome. Phantom sensations can occur as passive proprioceptive sensations of the limb's presence, or more active sensations such as perceived movement, pressure, pain, itching, or temperature. There are a variety of theories concerning the etiology of phantom limb sensations and experience. One is the concept of "proprioceptive memory", which argues that the brain retains a memory of specific limb positions and that after amputation there is a conflict between the visual system, which actually sees that the limb is missing, and the memory system which remembers the limb as a functioning part of the body.[30] Phantom sensations and phantom pain may also occur after the removal of body parts other than the limbs, such as after amputation of the breast, extraction of a tooth (phantom tooth pain), or removal of an eye (phantom eye syndrome).

Temporary impairment of proprioception has also been known to occur from an overdose of vitamin B6 (pyridoxine and pyridoxamine). Most of the impaired function returns to normal shortly after the amount of the vitamin in the body returns to a level that is closer to that of the physiological norm. Impairment can also be caused by cytotoxic factors such as chemotherapy.

It has been proposed that even common tinnitus and the attendant hearing frequency-gaps masked by the perceived sounds may cause erroneous proprioceptive information to the balance and comprehension centers of the brain, precipitating mild confusion.

Proprioception is permanently impaired in patients that suffer from joint hypermobility or Ehlers-Danlos syndrome (a genetic condition that results in weak connective tissue throughout the body).[31] It can also be permanently impaired from viral infections as reported by Sacks. The catastrophic effect of major proprioceptive loss is reviewed by Robles-De-La-Torre (2006).[32]

Proprioception is also permanently impaired in physiological aging (presbypropria).[33]

Parkinson's disease is characterized by a decline in motor function as a result of neurodegeneration. It is likely that some of the symptoms of Parkinson's disease are in part related to disrupted proprioception.[34] Whether this symptom is caused by degeneration of proprioceptors in the periphery or disrupted signaling in the brain or spinal cord is an open question.

Diagnosis

"Joint position matching" is an established protocol for measuring proprioception, and joint position sense specifically, without the aid of visual or vestibular information.[35] During such tasks, individuals are blindfolded while a joint is moved to a specific angle for a given period of time, returned to neutral, and the subjects are asked to replicate the specified angle. Measured by constant and absolute errors, ability to accurately identify joint angles over a series of conditions is the most accurate means of determining proprioceptive acuity in isolation to date.

Recent investigations have shown that hand dominance, participant age, active versus passive matching, and presentation time of the angle can all affect performance on joint position matching tasks.[36] Joint position matching has been used in clinical settings in both the upper and lower extremities.

Proprioception is tested by American police officers using the field sobriety testing to check for alcohol intoxication. The subject is required to touch his or her nose with eyes closed; people with normal proprioception may make an error of no more than 20 mm (0.79 in), while people suffering from impaired proprioception (a symptom of moderate to severe alcohol intoxication) fail this test due to difficulty locating their limbs in space relative to their noses.

Training

Proprioception is what allows someone to learn to walk in complete darkness without losing balance. During the learning of any new skill, sport, or art, it is usually necessary to become familiar with some proprioceptive tasks specific to that activity. Without the appropriate integration of proprioceptive input, an artist would not be able to brush paint onto a canvas without looking at the hand as it moved the brush over the canvas; it would be impossible to drive an automobile because a motorist would not be able to steer or use the pedals while looking at the road ahead; a person could not touch type or perform ballet; and people would not even be able to walk without watching where they put their feet.

Oliver Sacks reported the case of a young woman who lost her proprioception due to a viral infection of her spinal cord.[37] At first she could not move properly at all or even control her tone of voice (as voice modulation is primarily proprioceptive). Later she relearned by using her sight (watching her feet) and inner ear only for movement while using hearing to judge voice modulation. She eventually acquired a stiff and slow movement and nearly normal speech, which is believed to be the best possible in the absence of this sense. She could not judge effort involved in picking up objects and would grip them painfully to be sure she did not drop them.

The proprioceptive sense can be sharpened through study of many disciplines. Examples are the Feldenkrais method[38] and the Alexander Technique. Juggling trains reaction time, spatial location, and efficient movement. Standing on a wobble board or balance board is often used to retrain or increase proprioception abilities, particularly as physical therapy for ankle or knee injuries. Slacklining is another method to increase proprioception.

Standing on one leg (stork standing) and various other body-position challenges are also used in such disciplines as yoga, Wing Chun and tai chi.[39] The vestibular system of the inner ear, vision and proprioception are the main three requirements for balance.[40] Moreover, there are specific devices designed for proprioception training, such as the exercise ball, which works on balancing the abdominal and back muscles.

History of study

The position-movement sensation was originally described in 1557 by Julius Caesar Scaliger as a "sense of locomotion".[41] Much later, in 1826, Charles Bell expounded the idea of a "muscle sense",[42] which is credited as one of the first descriptions of physiologic feedback mechanisms.[43] Bell's idea was that commands are carried from the brain to the muscles, and that reports on the muscle's condition would be sent in the reverse direction. In 1847 the London neurologist Robert Todd highlighted important differences in the anterolateral and posterior columns of the spinal cord, and suggested that the latter were involved in the coordination of movement and balance.[44]

At around the same time, Moritz Heinrich Romberg, a Berlin neurologist, was describing unsteadiness made worse by eye closure or darkness, now known as the eponymous Romberg's sign, once synonymous with tabes dorsalis, that became recognised as common to all proprioceptive disorders of the legs. Later, in 1880, Henry Charlton Bastian suggested "kinaesthesia" instead of "muscle sense" on the basis that some of the afferent information (back to the brain) comes from other structures, including tendons, joints, and skin.[45] In 1889, Alfred Goldscheider suggested a classification of kinaesthesia into three types: muscle, tendon, and articular sensitivity.[46]

In 1906, Charles Scott Sherrington published a landmark work that introduced the terms "proprioception", "interoception", and "exteroception".[47] The "exteroceptors" are the organs that provide information originating outside the body, such as the eyes, ears, mouth, and skin. The interoceptors provide information about the internal organs, and the "proprioceptors" provide information about movement derived from muscular, tendon, and articular sources. Using Sherrington's system, physiologists and anatomists search for specialised nerve endings that transmit mechanical data on joint capsule, tendon and muscle tension (such as Golgi tendon organs and muscle spindles), which play a large role in proprioception.

Primary endings of muscle spindles "respond to the size of a muscle length change and its speed" and "contribute both to the sense of limb position and movement".[48] Secondary endings of muscle spindles detect changes in muscle length, and thus supply information regarding only the sense of position.[48] Essentially, muscle spindles are stretch receptors.[49] It has been accepted that cutaneous receptors also contribute directly to proprioception by providing "accurate perceptual information about joint position and movement", and this knowledge is combined with information from the muscle spindles.[50]

Etymology

Proprioception is from Latin proprius, meaning "one's own", "individual", and capio, capere, to take or grasp. Thus to grasp one's own position in space, including the position of the limbs in relation to each other and the body as a whole.

The word kinesthesia or kinæsthesia (kinesthetic sense) refers to movement sense, but has been used inconsistently to refer either to proprioception alone or to the brain's integration of proprioceptive and vestibular inputs. Kinesthesia is a modern medical term composed of elements from Greek; kinein "to set in motion; to move" (from PIE root *keie- "to set in motion") + aisthesis "perception, feeling" (from PIE root *au- "to perceive") + Greek abstract noun ending -ia (corresponds to English -hood e.g. motherhood).

Plants

Terrestrial plants control the orientation of their primary growth through the sensing of several vectorial stimuli such as the light gradient or the gravitational acceleration. This control has been called tropism. However, a quantitative study of shoot gravitropism demonstrated that, when a plant is tilted, it cannot recover a steady erected posture under the sole driving of the sensing of its angular deflection versus gravity. An additional control through the continuous sensing of its curvature by the organ and the subsequent driving an active straightening process are required.[6][7][51] Being a sensing by the plant of the relative configuration of its parts, it has been called proprioception. This dual sensing and control by gravisensing and proprioception has been formalized into a unifying mathematical model simulating the complete driving of the gravitropic movement. This model has been validated on 11 species sampling the phylogeny of land angiosperms, and on organs of very contrasted sizes, ranging from the small germination of wheat (coleoptile) to the trunk of poplar trees.[6][7] This model also shows that the entire gravitropic dynamics is controlled by a single dimensionless number called the "Balance Number", and defined as the ratio between the sensitivity to the inclination angle versus gravity and the proprioceptive sensitivity. This model has been extended to account for the effects of the passive bending of the organ under its self-weight, suggesting that proprioception is active even in very compliant stems, although they may not be able to efficiently straighten depending on their elastic deformation under the gravitational pull.[52] Further studies have shown that the cellular mechanism of proprioception in plants involves myosin and actin, and seems to occur in specialized cells.[53] Proprioception was then found to be involved in other tropisms and to be central also to the control of nutation [54]

These results change the view we have on plant sensitivity. They are also providing concepts and tools for the breeding of crops that are resilient to lodging, and of trees with straight trunks and homogeneous wood quality.[55]

The discovery of proprioception in plants has generated an interest in the popular science and generalist media.[56][57] This is because this discovery questions a long-lasting a priori that we have on plants. In some cases this has led to a shift between proprioception and self-awareness or self-consciousness. There is no scientific ground for such a semantic shift. Indeed, even in animals, proprioception can be unconscious; so it is thought to be in plants.[7][57]

gollark: It seems more like a bug of some kind, if it removed krists from your account despite the name being invalid.
gollark: Basically, even ignoring security issues, it would probably have more overhead than just running the chunks on the server would, and introduce an exciting new set of problems.
gollark: Also, you would run into issues like having to synchronize state with the server still, random connection outages/failures of your computer, interaction across chunk borders being run on different computers being *interesting*, possibly claims...
gollark: Never trust the client.
gollark: That is impossible to do securely.

See also

References
  1. "Proprioception". Merriam-Webster Dictionary.
  2. "proprioceptive – definition of proprioceptive in English from the Oxford dictionary". OxfordDictionaries.com. Retrieved 2016-01-20.
  3. Tuthill, John C.; Azim, Eiman (March 2018). "Proprioception". Current Biology. 28 (5): R194–R203. doi:10.1016/j.cub.2018.01.064. PMID 29510103.
  4. Gandevia, Simon; Proske, Uwe (1 September 2016). "Proprioception: The Sense Within". The Scientist. Retrieved 25 July 2018.
  5. Tuthill & Azim (5 March 2018). "Proprioception". Current Biology. 28 (5): R194–R203. doi:10.1016/j.cub.2018.01.064. PMID 29510103.
  6. Bastien, Renaud; Bohr, Tomas; Moulia, Bruno; Douady, Stéphane (2013-01-08). "Unifying model of shoot gravitropism reveals proprioception as a central feature of posture control in plants". Proceedings of the National Academy of Sciences. 110 (2): 755–760. Bibcode:2013PNAS..110..755B. doi:10.1073/pnas.1214301109. ISSN 0027-8424. PMC 3545775. PMID 23236182.
  7. Hamant, Olivier; Moulia, Bruno (2016-10-01). "How do plants read their own shapes?". New Phytologist. 212 (2): 333–337. doi:10.1111/nph.14143. ISSN 1469-8137. PMID 27532273.
  8. Lundberg, Malmgren, & Schomburg (Nov 1978). "Role of joint afferents in motor control exemplified by effects on reflex pathways from Ib afferents". The Journal of Physiology. 284: 327–343. doi:10.1113/jphysiol.1978.sp012543. PMC 1282824. PMID 215758.CS1 maint: multiple names: authors list (link)
  9. Bush (1965). "Proprioception by the Coxo-Basal Chordotonal Organ, CB, in Legs of the Crab, Carcinus Maenas". Journal of Experimental Biology. 42: 285–97. PMID 14323766.
  10. Murphy, Wong, & Kwan (July 1975). "Afferent-efferent linkages in motor cortex for single forelimb muscles". Journal of Neurophysiology. 38 (4): 990–1014. doi:10.1152/jn.1975.38.4.990. PMID 125786.CS1 maint: multiple names: authors list (link)
  11. Chapman (April 1965). "Campaniform Sensilla on the tactile spines of the legs of the cockroach". Journal of Experimental Biology. 42: 191–203. PMID 14323763.
  12. Bräunig, Hustert, & Pflüger (1981). "Distribution and specific central projections of mechanoreceptors in the thorax and proximal leg joints of locusts. I. Morphology, location and innervation of internal proprioceptors of pro- and metathorax and their central projections". Cell and Tissue Research. 216 (1): 57–77. doi:10.1007/bf00234545. PMID 7226209.CS1 maint: multiple names: authors list (link)
  13. Bässler, U.; Büschges, A. (June 1998). "Pattern generation for stick insect walking movements--multisensory control of a locomotor program". Brain Research. Brain Research Reviews. 27 (1): 65–88. doi:10.1016/S0165-0173(98)00006-X. PMID 9639677.
  14. Tuthill, John C.; Wilson, Rachel I. (October 2016). "Mechanosensation and Adaptive Motor Control in Insects". Current Biology. 26 (20): R1022–R1038. doi:10.1016/j.cub.2016.06.070. PMC 5120761. PMID 27780045.
  15. Fix, James D. (2002). Neuroanatomy. Hagerstown, MD: Lippincott Williams & Wilkins. pp. 127. ISBN 978-0-7817-2829-4.
  16. Swenson RS. "Review of Clinical and Functional Neuroscience, Chapter 7A: Somatosensory Systems". (online version Dartmouth college). Archived from the original on 2008-04-05. Retrieved 2008-04-10.
  17. Siegel, Allan (2010). Essential Neuroscience. Lippincott Williams & Wilkins. p. 263.
  18. "TMJ, Forward Head Posture and Neck Pain". Freedom From Pain Institute. Archived from the original on 2013-10-05. Retrieved 3 October 2013.
  19. Sherrington CS (1907). "On the proprioceptive system, especially in its reflex aspect". Brain. 29 (4): 467–85. doi:10.1093/brain/29.4.467. Archived from the original on 2008-12-06. Retrieved 2008-02-15.
  20. Walker, R. G.; Willingham, A. T.; Zuker, C. S. (2000). "A Drosophila mechanosensory transduction channel". Science. 287 (5461): 2229–2234. Bibcode:2000Sci...287.2229W. CiteSeerX 10.1.1.646.2497. doi:10.1126/science.287.5461.2229. PMID 10744543.
  21. Li, W.; Feng, Z.; Sternberg, P. W.; Shawn Xu, X. Z. (2006). "A C. Elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue". Nature. 440 (7084): 684–687. Bibcode:2006Natur.440..684L. doi:10.1038/nature04538. PMC 2865900. PMID 16572173.
  22. Shin, J. -B.; Adams, D.; Paukert, M.; Siba, M.; Sidi, S.; Levin, M.; Gillespie, P. G.; Gründer, S. (2005). "Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells". Proceedings of the National Academy of Sciences. 102 (35): 12572–12577. Bibcode:2005PNAS..10212572S. doi:10.1073/pnas.0502403102. PMC 1194908. PMID 16116094.
  23. Sidi, S.; Friedrich, R. W.; Nicolson, T. (2003). "NompC TRP Channel Required for Vertebrate Sensory Hair Cell Mechanotransduction". Science. 301 (5629): 96–99. Bibcode:2003Sci...301...96S. doi:10.1126/science.1084370. PMID 12805553.
  24. Woo SH, Lukacs V, de-Nooij JC, Zaytseva D, Criddle CR, Francisco A, Jessell TM, Wilkinson KA, Patapounian A (2015). "Piezo2 is the principal mechanotransduction channel for proprioception". Nature Neuroscience. 18 (12): 1756–1762. doi:10.1038/nn.4162. PMC 4661126. PMID 26551544.
  25. Robles-De-La-Torre G, Hayward V (2001). "Force can overcome object geometry in the perception of shape through active touch" (PDF). Nature. 412 (6845): 445–8. Bibcode:2001Natur.412..445R. doi:10.1038/35086588. PMID 11473320. Archived from the original (PDF) on 2006-10-03. Retrieved 2006-10-03.
  26. the MIT Technology Review article "The Cutting Edge of Haptics"
  27. Jan, Y. N. and Jan, L. Y. (1993). The peripheral nervous system. In: The Development of Drosophila melanogaster (ed. Bate, M and Arias, A. M.), pp 1207-1244. New York, Cold Spring Harbor Laboratory Press.
  28. Maier, A., 1997. Development and regeneration of muscle spindles in mammals and birds. The International journal of developmental biology, 41(1), pp.1-17.
  29. Ehrsson H, Kito T, Sadato N, Passingham R, Naito E (2005). "Neural substrate of body size: illusory feeling of shrinking of the waist". PLoS Biol. 3 (12): e412. doi:10.1371/journal.pbio.0030412. PMC 1287503. PMID 16336049.
  30. Weeks, S.R.; Anderson-Barnes, V.C.; Tsao, J. (2010). "Phantom limb pain: Theories and therapies" (PDF). The Neurologist. 16 (5): 277–286. doi:10.1097/nrl.0b013e3181edf128. PMID 20827116. Archived from the original (PDF) on 2011-08-12.
  31. Castori M (2012). "Ehlers-danlos syndrome, hypermobility type: an underdiagnosed hereditary connective tissue disorder with mucocutaneous, articular, and systemic manifestations". ISRN Dermatology. 2012: 1–22. doi:10.5402/2012/751768. PMC 3512326. PMID 23227356.
  32. Robles-De-La-Torre G (2006). "The Importance of the Sense of Touch in Virtual and Real Environments" (PDF). IEEE Multimedia. 13 (3): 24–30. doi:10.1109/MMUL.2006.69. Archived from the original (PDF) on 2014-01-24. Retrieved 2006-10-07.
  33. Boisgontier, MP; Olivier, I; Chenu, O; Nougier, V (2012). "Presbypropria: The effects of physiological ageing on proprioceptive control". Age (Dordrecht, Netherlands). 34 (5): 1179–94. doi:10.1007/s11357-011-9300-y. PMC 3448996. PMID 21850402.
  34. Konczak, J., Corcos, D.M., Horak, F., Poizner, H., Shapiro, M., Tuite, P., Volkmann, J. and Maschke, M., 2009. Proprioception and motor control in Parkinson's disease. Journal of motor behavior, 41(6), pp.543-552.
  35. Goble, DJ; Noble, BC; Brown, SH (2010). "Where was my arm again? Memory-based matching of proprioceptive targets is enhanced by increased target presentation time" (PDF). Neuroscience Letters. 481 (1): 54–8. doi:10.1016/j.neulet.2010.06.053. PMID 20600603. Archived from the original (PDF) on 2014-12-19. Retrieved 2013-03-15.
  36. Goble, DJ (2010). "Proprioceptive acuity assessment via joint position matching: From basic science to general practice". Physical Therapy. 90 (8): 1176–84. doi:10.2522/ptj.20090399. PMID 20522675.
  37. Sacks, O.. "The Disembodied Lady", in The Man Who Mistook His Wife for a Hat and his autobiographical case study A Leg to Stand On.
  38. Connors, Karol A.; Galea, Mary P.; Said, Catherine M. (2011). "Feldenkrais Method Balance Classes Improve Balance in Older Adults: A Controlled Trial". Evidence-Based Complementary and Alternative Medicine. 2011: 1–9. doi:10.1093/ecam/nep055. PMC 3137762. PMID 19553385.
  39. cheng man ch'ing (1981). T'ai Chi Ch'uan. Blue Snake Books usa. pp. 86, 88. ISBN 978-0-913028-85-8.
  40. Hanc, John. "Staying on Balance, With the Help of Exercises". The New York Times. Archived from the original on 2017-10-11. Retrieved 11 October 2017.
  41. Jerosch, Jörg; Heisel, Jürgen (May 2010). Management der Arthrose: Innovative Therapiekonzepte (in German). Deutscher Ärzteverlag. p. 107. ISBN 978-3-7691-0599-5. Retrieved 8 April 2011.
  42. Singh, Arun Kumar (September 1991). The Comprehensive History of Psychology. Motilal Banarsidass. p. 66. ISBN 978-81-208-0804-1. Retrieved 8 April 2011.
  43. Dickinson, John (1976). Proprioceptive control of human movement. Princeton Book Co. p. 4. Retrieved 8 April 2011.
  44. Todd, Robert Bentley (1847). The Cyclopaedia of Anatomy and Physiology Vol. 4. London: Longmans. pp. 585–723.
  45. Foster, Susan Leigh (15 December 2010). Choreographing Empathy: Kinesthesia in Performance. Taylor & Francis. p. 74. ISBN 978-0-415-59655-8. Retrieved 8 April 2011.
  46. Brookhart, John M.; Mountcastle, Vernon B. (Vernon Benjamin); Geiger, Stephen R. (1984). The Nervous system: Sensory processes; volume editor: Ian Darian-Smith. American Physiological Society. p. 784. ISBN 978-0-683-01108-1. Retrieved 8 April 2011.
  47. Sherrington, C.S.(1906). The Integrative Action of the Nervous System. NewHaven, CT:YaleUniversityPress.
  48. Proske, U; Gandevia, SC (2009). "The kinaesthetic senses". The Journal of Physiology. 587 (Pt 17): 4139–4146. doi:10.1113/jphysiol.2009.175372. PMC 2754351. PMID 19581378.
  49. Winter, JA; Allen, TJ; Proske, U (2005). "Muscle spindle signals combine with the sense of effort to indicate limb position". The Journal of Physiology. 568 (Pt 3): 1035–46. doi:10.1113/jphysiol.2005.092619. PMC 1464181. PMID 16109730.
  50. Collins, DF; Refshauge, KM; Todd, G; Gandevia, SC (2005). "Cutaneous receptors contribute to kinesthesia at the index finger, elbow, and knee". Journal of Neurophysiology. 94 (3): 1699–706. doi:10.1152/jn.00191.2005. PMID 15917323.
  51. "From gravitropism to dynamical posture control: proprioception in plants". University of Cambridge. Archived from the original on 2017-08-05. Retrieved 5 August 2017.
  52. Chelakkot, Raghunath; Mahadevan, L. (March 2017). "On the growth and form of shoots". Journal of the Royal Society Interface. 14 (128): 20170001. doi:10.1098/rsif.2017.0001. ISSN 1742-5689. PMC 5378141. PMID 28330990.
  53. Okamoto, Keishi; Ueda, Haruko; Shimada, Tomoo; Tamura, Kentaro; Kato, Takehide; Tasaka, Masao; Morita, Miyo Terao; Hara-Nishimura, Ikuko (2015-03-23). "Regulation of organ straightening and plant posture by an actin–myosin XI cytoskeleton". Nature Plants. 1 (4): 15031. doi:10.1038/nplants.2015.31. hdl:2433/197219. ISSN 2055-0278. PMID 27247032.
  54. Bastien, Renaud; Meroz, Yasmine (2016-12-06). "The Kinematics of Plant Nutation Reveals a Simple Relation between Curvature and the Orientation of Differential Growth". PLOS Computational Biology. 12 (12): e1005238. arXiv:1603.00459. Bibcode:2016PLSCB..12E5238B. doi:10.1371/journal.pcbi.1005238. ISSN 1553-7358. PMC 5140061. PMID 27923062.
  55. Gardiner, Barry; Berry, Peter; Moulia, Bruno (2016). "Review: Wind impacts on plant growth, mechanics and damage". Plant Science. 245: 94–118. doi:10.1016/j.plantsci.2016.01.006. PMID 26940495.
  56. Gabbatiss, Josh (10 January 2017). "Plants can see, hear and smell – and respond". Archived from the original on 2017-08-06. Retrieved 5 August 2017.
  57. plantguy (28 May 2017). "The Selfish Plant 4 – Plant Proprioception?". How Plants Work. Retrieved 5 August 2017.
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