Picornain 2A
Picornain 2A (EC 3.4.22.29, picornavirus endopeptidase 2A, poliovirus protease 2A, rhinovirus protease 2A, 2A protease, 2A proteinase, protease 2A, proteinase 2Apro, picornaviral 2A proteinase, Y-G proteinase 2A, poliovirus proteinase 2A, poliovirus protease 2Apro) is a protease enzyme.[1][2][3] This enzyme catalyses the following chemical reaction:
- Selective cleavage of Tyr-Gly bond in picornavirus polyprotein
| Picornain 2A | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.22.29 | ||||||||
| CAS number | 103406-62-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme is coded by entero-, rhino-, aphto- and cardioviruses.
References
- Bazan JF, Fletterick RJ (November 1988). "Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 7872–6. doi:10.1073/pnas.85.21.7872. PMC 282299. PMID 3186696.
- König H, Rosenwirth B (April 1988). "Purification and partial characterization of poliovirus protease 2A by means of a functional assay". Journal of Virology. 62 (4): 1243–50. PMC 253133. PMID 2831385.
- Kräusslich HG, Wimmer E (1988). "Viral proteinases". Annual Review of Biochemistry. 57: 701–54. doi:10.1146/annurev.bi.57.070188.003413. PMID 3052288.
External links
- Picornain+2A at the US National Library of Medicine Medical Subject Headings (MeSH)
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