PNRC1

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[4][5]

PNRC1
Identifiers
Aliases	PNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDs	OMIM: 606714 MGI: 1917838 HomoloGene: 4960 GeneCards: PNRC1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,080,751 bp[1] End 89,085,160 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • P-body • cell nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10957	108767
Ensembl	ENSG00000146278	n/a
UniProt	Q12796 Q49A59	Q3TWH3
RefSeq (mRNA)	NM_006813	NM_001033225
RefSeq (protein)	NP_006804	NP_001028397
Location (UCSC)	Chr 6: 89.08 – 89.09 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[6][7] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000146278 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
5. "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
6. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/me.14.7.986. PMID 10894149.
7. Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhou D, Chen B, Ye JJ, Chen S (2004). "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction". Oncogene. 23 (31): 5394–404. doi:10.1038/sj.onc.1207695. PMID 15122321.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. CiteSeerX 10.1.1.621.2877. doi:10.1074/jbc.274.32.22373. PMID 10428808.

External links

• PNRC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C108