PPARGC1B

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.[5][6][7]

PPARGC1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3SP6
Identifiers
Aliases	PPARGC1B, ERRL1, PERC, PGC-1(beta), PGC1B, PPARG coactivator 1 beta
External IDs	OMIM: 608886 MGI: 2444934 HomoloGene: 15776 GeneCards: PPARGC1B
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 149,730,298 bp[1] End 149,855,022 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E1 Start 61,298,136 bp[2] End 61,400,431 bp[2]
Gene ontology Molecular function • GO:0001104 transcription cofactor activity • AF-2 domain binding • ligand-dependent nuclear receptor transcription coactivator activity • RNA binding • nucleic acid binding • transcription factor binding • estrogen receptor binding Cellular component • mediator complex • mitochondrion • cell nucleus • nucleoplasm Biological process • transcription from mitochondrial promoter • regulation of transcription, DNA-templated • ossification • actin filament organization • positive regulation of osteoclast differentiation • positive regulation of sequence-specific DNA binding transcription factor activity • response to glucocorticoid • bone trabecula formation • positive regulation of bone resorption • transcription, DNA-templated • positive regulation of transcription, DNA-templated • cellular response to reactive oxygen species • positive regulation of alkaline phosphatase activity • response to cAMP • positive regulation of phosphorylation • negative regulation of transcription, DNA-templated • intracellular estrogen receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter • positive regulation of cold-induced thermogenesis • regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	133522	170826
Ensembl	ENSG00000155846	ENSMUSG00000033871
UniProt	Q86YN6	Q8VHJ7
RefSeq (mRNA)	NM_001172698 NM_001172699 NM_133263	NM_133249 NM_001364996
RefSeq (protein)	NP_001166169 NP_001166170 NP_573570	NP_573512 NP_001351925
Location (UCSC)	Chr 5: 149.73 – 149.86 Mb	Chr 18: 61.3 – 61.4 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• PPARGC1A
• Peroxisome proliferator-activated receptor
• Peroxisome proliferator-activated receptor alpha
• Peroxisome proliferator-activated receptor delta
• Peroxisome proliferator-activated receptor gamma
• Transcription coregulator

References

1. GRCh38: Ensembl release 89: ENSG00000155846 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033871 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ek J, Andersen G, Urhammer SA, Gaede PH, Drivsholm T, Borch-Johnsen K, Hansen T, Pedersen O (Jan 2002). "Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus". Diabetologia. 44 (12): 2220–6. doi:10.1007/s001250100032. PMID 11793024.
6. Kressler D, Schreiber SN, Knutti D, Kralli A (Apr 2002). "The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha". J Biol Chem. 277 (16): 13918–25. doi:10.1074/jbc.M201134200. PMID 11854298.
7. "Entrez Gene: PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta".

Further reading

• Handschin C, Spiegelman BM (2007). "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism". Endocr. Rev. 27 (7): 728–35. doi:10.1210/er.2006-0037. PMID 17018837.
• Esterbauer H, Oberkofler H, Krempler F, Patsch W (2000). "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression". Genomics. 62 (1): 98–102. doi:10.1006/geno.1999.5977. PMID 10585775.
• Knutti D, Kaul A, Kralli A (2000). "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen". Mol. Cell. Biol. 20 (7): 2411–22. doi:10.1128/MCB.20.7.2411-2422.2000. PMC 85422. PMID 10713165.
• Lin J, Puigserver P, Donovan J, et al. (2002). "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor". J. Biol. Chem. 277 (3): 1645–8. doi:10.1074/jbc.C100631200. PMID 11733490.
• Lacquemant C, Chikri M, Boutin P, et al. (2002). "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians". Diabetologia. 45 (4): 602–3, author reply 604. doi:10.1007/s00125-002-0783-z. PMID 12032643.
• Hara K, Tobe K, Okada T, et al. (2003). "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes". Diabetologia. 45 (5): 740–3. doi:10.1007/s00125-002-0803-z. PMID 12107756.
• Huss JM, Kopp RP, Kelly DP (2002). "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha". J. Biol. Chem. 277 (43): 40265–74. doi:10.1074/jbc.M206324200. PMID 12181319.
• Hentschke M, Süsens U, Borgmeyer U (2003). "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma". Biochem. Biophys. Res. Commun. 299 (5): 872–9. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shiraki T, Sakai N, Kanaya E, Jingami H (2003). "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state". J. Biol. Chem. 278 (13): 11344–50. doi:10.1074/jbc.M212859200. PMID 12551939.
• Hammarstedt A, Jansson PA, Wesslau C, et al. (2003). "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance". Biochem. Biophys. Res. Commun. 301 (2): 578–82. doi:10.1016/S0006-291X(03)00014-7. PMID 12565902.
• Meirhaeghe A, Crowley V, Lenaghan C, et al. (2003). "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo". Biochem. J. 373 (Pt 1): 155–65. doi:10.1042/BJ20030200. PMC 1223480. PMID 12678921.
• Patti ME, Butte AJ, Crunkhorn S, et al. (2003). "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. doi:10.1073/pnas.1032913100. PMC 166252. PMID 12832613.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ling C, Poulsen P, Carlsson E, et al. (2004). "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins". J. Clin. Invest. 114 (10): 1518–26. doi:10.1172/JCI21889. PMC 525741. PMID 15546003.
• Andersen G, Wegner L, Yanagisawa K, et al. (2006). "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity". J. Med. Genet. 42 (5): 402–7. doi:10.1136/jmg.2004.026278. PMC 1736055. PMID 15863669.
• Staiger H, Staiger K, Haas C, et al. (2005). "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro". Diabetologia. 48 (10): 2115–8. doi:10.1007/s00125-005-1895-z. PMID 16132959.
• Wirtenberger M, Tchatchou S, Hemminki K, et al. (2006). "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer". Carcinogenesis. 27 (11): 2201–8. doi:10.1093/carcin/bgl067. PMID 16704985.

External links

• PPARGC1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C21

This article incorporates text from the United States National Library of Medicine, which is in the public domain.