CRTC3

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene.[5][6][7]

CRTC3
Identifiers
Aliases	CRTC3, TORC-3, TORC3, CREB regulated transcription coactivator 3
External IDs	OMIM: 608986 MGI: 1917711 HomoloGene: 11248 GeneCards: CRTC3
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,529,923 bp[1] End 90,645,345 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D3 Start 80,586,627 bp[2] End 80,688,877 bp[2]
Gene ontology Molecular function • cAMP response element binding protein binding • GO:0001948 protein binding Cellular component • cell nucleus • nucleoplasm • cytoplasm • cytosol Biological process • energy homeostasis • macrophage activation • positive regulation of CREB transcription factor activity • GO:0022415 viral process • negative regulation of lipid catabolic process • regulation of transcription, DNA-templated • protein homotetramerization • negative regulation of cAMP-mediated signaling • transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64784	70461
Ensembl	ENSG00000140577	ENSMUSG00000030527
UniProt	Q6UUV7	Q91X84
RefSeq (mRNA)	NM_001042574 NM_022769	NM_173863
RefSeq (protein)	NP_001036039 NP_073606	NP_776288
Location (UCSC)	Chr 15: 90.53 – 90.65 Mb	Chr 7: 80.59 – 80.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene has been shown to be linked to weight gain.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000140577 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030527 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
6. Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
7. "Entrez Gene: CRTC3 CREB regulated transcription coactivator 3".
8. Song Y, Altarejos J, Goodarzi MO, Inoue H, Guo X, Berdeaux R, Kim JH, Goode J, Igata M, Paz JC, Hogan MF, Singh PK, Goebel N, Vera L, Miller N, Cui J, Jones MR, Chen YD, Taylor KD, Hsueh WA, Rotter JI, Montminy M (Dec 2010). "CRTC3 links catecholamine signalling to energy balance". Nature. 468 (7326): 933–939. doi:10.1038/nature09564. PMC 3025711. PMID 21164481.

Further reading

• Hishiki T, Ohshima T, Ego T, Shimotohno K (Sep 2007). "BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3". The Journal of Biological Chemistry. 282 (39): 28335–43. doi:10.1074/jbc.M702656200. PMID 17644518.
• Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC (Sep 2006). "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America. 103 (39): 14379–84. doi:10.1073/pnas.0606714103. PMC 1569674. PMID 16980408.
• Koga H, Ohshima T, Shimotohno K (December 2004). "Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3". The Journal of Biological Chemistry. 279 (51): 52978–83. doi:10.1074/jbc.M409021200. PMID 15466468.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• CRTC3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CRTC3 genome location and CRTC3 gene details page in the UCSC Genome Browser.