MN1 (gene)

MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter.[5] Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.

MN1
Identifiers
Aliases	MN1, MGCR, MGCR1, MGCR1-PEN, dJ353E16.2, meningioma (disrupted in balanced translocation) 1, MN1 proto-oncogene, transcriptional regulator, CEBALID
External IDs	OMIM: 156100 MGI: 1261813 HomoloGene: 37620 GeneCards: MN1
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.1 Start 27,748,277 bp[1] End 27,801,756 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 53.86 cM Start 111,417,362 bp[2] End 111,457,033 bp[2]
Gene ontology Molecular function • molecular function Cellular component • cellular component Biological process • multicellular organism development • intramembranous ossification • regulation of transcription, DNA-templated • transcription, DNA-templated • biological process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4330	433938
Ensembl	ENSG00000169184	ENSMUSG00000070576
UniProt	Q10571	D3YWE6
RefSeq (mRNA)	NM_002430	NM_001081235
RefSeq (protein)	NP_002421	NP_001074704
Location (UCSC)	Chr 22: 27.75 – 27.8 Mb	Chr 5: 111.42 – 111.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

MN1 is a transcription coregulator that enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300.[6] MN1 also acts as a coactivator of the vitamin D receptor.[7]

Clinical significance

Its inactivation may be part of the cause of certain meningiomas.[5] A potential link to leukemia[8] including acute myeloid leukemia[9] has also been described.

Mutations in this gene have been associated with an atypical form of rhombencephalosynapsis.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000169184 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070576 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, et al. (April 1995). "Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma". Oncogene. 10 (8): 1521–8. PMID 7731706.
6. van Wely KH, Molijn AC, Buijs A, Meester-Smoor MA, Aarnoudse AJ, Hellemons A, et al. (February 2003). "The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription". Oncogene. 22 (5): 699–709. doi:10.1038/sj.onc.1206124. PMID 12569362.
7. Sutton AL, Zhang X, Ellison TI, Macdonald PN (September 2005). "The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation". Molecular Endocrinology. 19 (9): 2234–44. doi:10.1210/me.2005-0081. PMID 15890672.
8. Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, et al. (April 1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705.
9. Grosveld GC (2007). "MN1, a novel player in human AML". Blood Cells, Molecules & Diseases. 39 (3): 336–9. doi:10.1016/j.bcmd.2007.06.009. PMC 2387274. PMID 17698380.
10. Mak CC, Doherty D, Lin AE, Vegas N, Cho MT, Viot G, et al. (December 2019). "MN1 C-terminal truncation syndrome is a novel neurodevelopmental and craniofacial disorder with partial rhombencephalosynapsis". Brain. doi:10.1093/brain/awz379. PMID 31834374.

Further reading

• Kawagoe H, Grosveld GC (December 2005). "MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice". Blood. 106 (13): 4278–86. doi:10.1182/blood-2005-04-1674. PMC 1895241. PMID 16081688.
• Schroeder T, Czibere A, Zohren F, Aivado M, Gattermann N, Germing U, Haas R (June 2009). "Meningioma 1 gene is differentially expressed in CD34 positive cells from bone marrow of patients with myelodysplastic syndromes with the highest expression in refractory anemia with excess of blasts and secondary acute myeloid leukemia". Leukemia & Lymphoma. 50 (6): 1043–6. doi:10.1080/10428190902913591. PMID 19391034.
• Meester-Smoor MA, Janssen MJ, Grosveld GC, de Klein A, van IJcken WF, Douben H, Zwarthoff EC (October 2008). "MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression". Carcinogenesis. 29 (10): 2025–34. doi:10.1093/carcin/bgn168. PMC 3202306. PMID 18632758.
• Carella C, Bonten J, Sirma S, Kranenburg TA, Terranova S, Klein-Geltink R, et al. (August 2007). "MN1 overexpression is an important step in the development of inv(16) AML". Leukemia. 21 (8): 1679–90. doi:10.1038/sj.leu.2404778. PMID 17525718.
• Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, et al. (September 2007). "MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML". Blood. 110 (5): 1639–47. doi:10.1182/blood-2007-03-080523. PMID 17494859.
• Langer C, Marcucci G, Holland KB, Radmacher MD, Maharry K, Paschka P, et al. (July 2009). "Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study". Journal of Clinical Oncology. 27 (19): 3198–204. doi:10.1200/JCO.2008.20.6110. PMC 2716941. PMID 19451432.
• Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, et al. (March 2008). "Toward a confocal subcellular atlas of the human proteome". Molecular & Cellular Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
• Kawagoe H, Grosveld GC (December 2005). "Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9". Blood. 106 (13): 4269–77. doi:10.1182/blood-2005-04-1679. PMC 1895240. PMID 16105979.
• Kandilci A, Grosveld GC (August 2009). "Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation". Blood. 114 (8): 1596–606. doi:10.1182/blood-2009-02-205443. PMC 2731639. PMID 19561324.
• Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, et al. (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061.
• Gastier JM, Brody T, Pulido JC, Businga T, Sunden S, Hu X, et al. (February 1996). "Development of a screening set for new (CAG/CTG)n dynamic mutations". Genomics. 32 (1): 75–85. doi:10.1006/geno.1996.0078. PMID 8786123.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Meester-Smoor MA, Molijn AC, Zhao Y, Groen NA, Groffen CA, Boogaard M, et al. (February 2007). "The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence". Journal of Molecular Endocrinology. 38 (1–2): 113–25. doi:10.1677/jme.1.02110. PMID 17242174.
• Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, et al. (April 1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705.