Nodaviridae

Nodaviridae is a family of viruses.[1] Vertebrates and invertebrates serve as natural hosts. There are currently nine species in this family, divided among 2 genera. Diseases associated with this family include: viral encephalopathy and retinopathy in fishes.[2][3]

Nodaviridae
Vacuoles in retina of Australian bass larva experimentally infected with Betanodavirus
Virus classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Kitrinoviricota
Class: Magsaviricetes
Order: Nodamuvirales
Family: Nodaviridae
Genera

Virology

The virus is not enveloped and has an icosahedral capsid (triangulation number=3) ranging from 29 to 35 nm in diameter. The capsid is constructed of 32 capsomers.[2]

The genome is linear, positive sense, bipartite (composed of two segments—RNA1 and RNA2) single stranded RNA consisting of 4500 nucleotides with a 5’ terminal methylated cap and a non-polyadenylated 3’ terminal.[2]

RNA1, which is ~3.1 kilobases in length, encodes a protein that has multiple functional domains: a mitochondrial targeting domain, a transmembrane domain, an RNA-dependent RNA polymerase (RdRp) domain, a self-interaction domain and an RNA capping domain. In addition, RNA1 encodes a subgenomic RNA3 that encodes protein B2, an RNA silencing inhibitor.[2] RNA2 encodes protein α, a viral capsid protein precursor, which is auto-cleaved into two mature proteins, a 38 kDa β protein and a 5 kDa γ protein, at a conserved Asn/Ala site during virus assembly.[2]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
BetanodavirusIcosahedralT=3Non-envelopedLinearSegmented
AlphanodavirusIcosahedralT=3Non-envelopedLinearSegmented

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by penetration into the host cell. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription, using the internal initiation model of subgenomic RNA transcription is the method of transcription. Vertebrates and invertebrates serve as the natural host. Transmission routes are contact and contamination.[2][3]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
BetanodavirusFishNoneUnknownLysisCytoplasmCytoplasmPassive diffusion, direct contact
AlphanodavirusInsects, mammals, fishesNoneUnknownLysisCytoplasmCytoplasmUnknown

Taxonomy

The members of the genus Alphanodavirus were originally isolated from insects while those of the genus Betanodavirus were isolated from fish. A small number of nodoviruses seem to lie outside either of these clades.[2]

While NoV remains the type species of Alphanodavirus, Flock house virus (FHV) is the best studied of the nodaviruses.[2]

History

The name of the family is derived from the Japanese village of Nodamura, Iwate Prefecture where Nodamura virus was first isolated from Culex tritaeniorhynchus mosquitoes.

gollark: But it is strictly better for you to defect.
gollark: If you both cooperate it's better.
gollark: `scp ./path other-thing:/home/matt/path`.
gollark: In noniterated games it is *strictly better* to defect, unless you somehow have access to your opponent's source code or whatever.
gollark: ???

References
  1. Sahul Hameed, AS; Ninawe, AS; Nakai, T; Chi, SC; Johnson, KL; ICTV Report, Consortium (January 2019). "ICTV Virus Taxonomy Profile: Nodaviridae". The Journal of General Virology. 100 (1): 3–4. doi:10.1099/jgv.0.001170. PMID 30431412.
  2. "ICTV Report Nodaviridae".
  3. "Viral Zone". ExPASy. Retrieved 15 June 2015.
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