Milbemycin
The milbemycins are a group of macrolides chemically related to the avermectins and were first isolated in 1972 from Streptomyces hygroscopicus. They are used in veterinary medicine as antiparasitic agents against worms, ticks and fleas.[1]
Mechanism of action
Like avermectins, milbemycins are products of fermentation by Streptomyces species. They have a similar mechanism of action, but a longer half-life than the avermectins. They open glutamate-sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer.
Examples
| Name | =R1 | =R2 | –R3 |
|---|---|---|---|
| Milbemectin | –H, (β)–OH | –H, –H | –CH3 : –CH2CH3 = 3:7 |
| Milbemycin oxime | =NOH | –H, –H | –CH3 : –CH2CH3 = 3:7 |
| Moxidectin | –H, (β)–OH | =NOCH3 | (Z)–C(CH3)=CH–CH(CH3)2[1] |
| Nemadectin | –H, (β)–OH | –H, (α)–OH | (Z)–C(CH3)=CH–CH(CH3)2[1] |
gollark: Well, if you're using Express, then:```javascriptapp.use(express.urlencoded())app.post("/", (req, res) => res.send(JSON.stringify(req.body)))```ought to work.
gollark: <@498244879894315027> What are you trying to access it *from*?
gollark: Look, it says there, > By design, the POST request method requests that a web server accepts the data enclosed in the body of the request message, most likely for storing it.
gollark: The urlencoded MIME type/format doesn't mean it's sent in the URL, just that it uses similar encoding to query strings.
gollark: POST data isn't in the URL though, it's sent as the body.
References
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.