Methyl aminolevulinate

Methyl aminolevulinate
Clinical data
AHFS/Drugs.com	Multum Consumer Information
ATC code	L01XD03 (WHO) ;
Identifiers
	IUPAC name Methyl 5-amino-4-oxopentanoate;
CAS Number	33320-16-0 ;
PubChem CID	16052023;
DrugBank	DB00992 ;
ChemSpider	13180320 ;
UNII	585NM85KYM;
ChEMBL	ChEMBL1096562 ;
CompTox Dashboard (EPA)	DTXSID3048570 ;
Chemical and physical data
Formula	C6H11NO3
Molar mass	145.158 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(CC(N)C(=O)OC)C;
	InChI InChI=1S/C6H11NO3/c1-4(8)3-5(7)6(9)10-2/h5H,3,7H2,1-2H3 ; Key:FLQHIIVXMKXKFT-UHFFFAOYSA-N ;
	(what is this?) (verify)

Methyl aminolevulinate (MAL) is a drug used as a sensitizer in photodynamic therapy. It is a prodrug that is metabolized to protoporphyrin IX. It is marketed as Metvix.

Metvix cream is applied topically and some time later the skin is illuminated with a proprietary red light (630 nm) source (medical lamp 'Aktilite') to activate the photosensitiser.

Metvix is developed by Photocure and Galderma has bought all rights to Metvix.[1]

Approvals and indications

Interim result of phototherapy for actinic keratosis with Metvix one week after exposure. Patient has light skin and blue eyes.

Methyl aminolevulinate is approved in New Zealand for treatment of basal cell carcinoma.[2]

It is now approved in many countries and has been used to treat non-melanoma skin cancer (including basal cell carcinoma).[3]

It has some advantages over Levulan.[4]

It has been reported as controversial in some quarters, with severe pain allegedly being experienced by some patients. [5]

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gollark: People: Inconsistent and Weird.

References

"Archived copy". Archived from the original on 2011-02-07. Retrieved 2010-09-10.CS1 maint: archived copy as title (link) Photocure divests Metvix to Galderma
http://dermnetnz.org/procedures/metvix-pdt.html "Methyl aminolevulinate photodynamic therapy (MAL PDT)"
http://www.medicalnewstoday.com/articles/36953.php "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006
http://findarticles.com/p/articles/mi_qa3931/is_200909/ai_n42040200/pg_13/ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T
http://www.abc.net.au/news/2013-11-16/concerns-raised-over-side-effects-of-skin-cancer-cream/5096496

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[1] "Archived copy". Archived from the original on 2011-02-07. Retrieved 2010-09-10.CS1 maint: archived copy as title (link) Photocure divests Metvix to Galderma

[2] ttp://dermnetnz.org/procedures/metvix-pdt.html "Methyl aminolevulinate photodynamic therapy (MAL PDT)"

[3] ttp://www.medicalnewstoday.com/articles/36953.php "New 5 Year Metvix-PDT Data Demonstrate Long-Term Efficacy & Reliability For NM Skin Cancer Treatment" 2006

[4] ttp://findarticles.com/p/articles/mi_qa3931/is_200909/ai_n42040200/pg_13/ Porphyrin and Nonporphyrin Photosensitizers in Oncology: Preclinical and Clinical Advances in Photodynamic Therapy Photochemistry and Photobiology, Sep/Oct 2009 by O'Connor, Aisling E, Gallagher, William M, Byrne, Annette T

[5] ttp://www.abc.net.au/news/2013-11-16/concerns-raised-over-side-effects-of-skin-cancer-cream/5096496