Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase (EC 1.14.13.81), Mg-protoporphyrin IX monomethyl ester (oxidative) cyclase) is an enzyme with systematic name magnesium-protoporphyrin-IX 13-monomethyl ester,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction
The chlorin ring system forms as the esterified propionate sidechain is cyclised on to the porphyrin ring of protoporphyrin IX to form divinylprotochlorophyllide
- magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 H+ + 3 O2 divinylprotochlorophyllide + 3 NADP+ + 5 H2O (overall reaction)
- (1a) magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O
- (1b) 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O
- (1c) 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + H+ + O2 divinylprotochlorophyllide + NADP+ + 2 H2O
| Magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.14.13.81 | ||||||||
| CAS number | 92353-62-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme requires Fe(II) for activity. It is part of the biosynthetic pathway to chlorophylls.[2][3]
See also
References
- Bollivar DW, Beale SI (September 1996). "The Chlorophyll Biosynthetic Enzyme Mg-Protoporphyrin IX Monomethyl Ester (Oxidative) Cyclase (Characterization and Partial Purification from Chlamydomonas reinhardtii and Synechocystis sp. PCC 6803)". Plant Physiology. 112 (1): 105–114. doi:10.1104/pp.112.1.105. PMC 157929. PMID 12226378.
- Willows, Robert D. (2003). "Biosynthesis of chlorophylls from protoporphyrin IX". Natural Product Reports. 20 (6): 327–341. doi:10.1039/B110549N. PMID 12828371.
- Bollivar, David W. (2007). "Recent advances in chlorophyll biosynthesis". Photosynthesis Research. 90 (2): 173–194. doi:10.1007/s11120-006-9076-6. PMID 17370354.
External links
- Magnesium-protoporphyrin+IX+monomethyl+ester+(oxidative)+cyclase at the US National Library of Medicine Medical Subject Headings (MeSH)
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