Lysine N-acetyltransferase
In enzymology, a lysine N-acetyltransferase (EC 2.3.1.32) is an enzyme that catalyzes the chemical reaction
- acetyl phosphate + L-lysine phosphate + N6-acetyl-L-lysine
| lysine N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Lysine N-acetyltransferase (EIS) hexamer, Mycobacterium tuberculosis | |||||||||
| Identifiers | |||||||||
| EC number | 2.3.1.32 | ||||||||
| CAS number | 37257-12-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are acetyl phosphate and L-lysine, whereas its two products are phosphate and N6-acetyl-L-lysine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-phosphate:L-lysine N6-acetyltransferase. Other names in common use include lysine acetyltransferase, and acetyl-phosphate:L-lysine 6-N-acetyltransferase. This enzyme participates in lysine degradation.
References
- PAIK WK, KIM S (1964). "ENZYMIC SYNTHESIS OF EPSILON-N-ACETYL-L-LYSINE". Arch. Biochem. Biophys. 108 (2): 221–9. doi:10.1016/0003-9861(64)90379-0. PMID 14240571.
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