KAT8 regulatory NSL complex subunit 1

Uncharacterized protein KIAA1267 is a protein that in humans is encoded by the KIAA1267 gene.[5][6]

KANSL1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CY1, 4CY2
Identifiers
Aliases	KANSL1, CENP-36, KDVS, KIAA1267, MSL1v1, NSL1, hMSL1v1, KAT8 regulatory NSL complex subunit 1
External IDs	OMIM: 612452 MGI: 1923969 HomoloGene: 9140 GeneCards: KANSL1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 46,029,916 bp[1] End 46,225,389 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 104,333,229 bp[2] End 104,468,861 bp[2]
Gene ontology Molecular function • histone acetyltransferase activity (H4-K5 specific) • histone acetyltransferase activity (H4-K16 specific) • GO:0001948 protein binding • histone acetyltransferase activity (H4-K8 specific) • histone acetyltransferase binding Cellular component • condensed chromosome kinetochore • histone acetyltransferase complex • MLL1 complex • chromosome, centromeric region • cell nucleus • kinetochore • chromosome • nucleoplasm • NSL complex Biological process • histone H4-K16 acetylation • histone H4-K8 acetylation • histone H4-K5 acetylation • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	284058	76719
Ensembl	ENSG00000278458 ENSG00000275867 ENSG00000120071	ENSMUSG00000018412
UniProt	Q7Z3B3	Q80TG1
RefSeq (mRNA)	NM_001193465 NM_001193466 NM_015443 NM_001379198	NM_001081045 NM_001359634 NM_001372458 NM_001372459 NM_001372460
RefSeq (protein)	NP_001180394 NP_001180395 NP_056258 NP_001366127	NP_001074514 NP_001346563 NP_001359387 NP_001359388 NP_001359389
Location (UCSC)	Chr 17: 46.03 – 46.23 Mb	Chr 11: 104.33 – 104.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

KIAA1267 has been shown to interact with CCDC85B.[7]

References

1. ENSG00000275867, ENSG00000120071 GRCh38: Ensembl release 89: ENSG00000278458, ENSG00000275867, ENSG00000120071 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018412 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
6. "Entrez Gene: KIAA1267 KIAA1267".
7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Poorkaj P, Kas A, D'Souza I, Zhou Y, Pham Q, Stone M, Olson MV, Schellenberg GD (2001). "A genomic sequence analysis of the mouse and human microtubule-associated protein tau". Mamm. Genome. 12 (9): 700–12. doi:10.1007/s00335-001-2044-8. PMID 11641718.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.