KIAA0174

IST1 homolog is a protein that in humans is encoded by the KIAA0174 gene.[5][6]

IST1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FRR, 3FRS, 4U7E, 4U7I, 4U7Y, 4WZX, 3JC1
Identifiers
Aliases	IST1, OLC1, KIAA0174, ESCRT-III associated factor, CHMP8, IST1 factor associated with ESCRT-III
External IDs	OMIM: 616434 MGI: 1919205 HomoloGene: 8849 GeneCards: IST1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.2 Start 71,845,996 bp[1] End 71,931,199 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 109,671,325 bp[2] End 109,693,260 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein domain specific binding • GO:0032403 macromolecular complex binding • GO:0001948 protein binding • MIT domain binding • cadherin binding Cellular component • cytoplasm • cytosol • centrosome • Flemming body • microtubule organizing center • extracellular exosome • cytoskeleton • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment • midbody • nuclear envelope • cell nucleus • extracellular region • azurophil granule lumen • intracellular membrane-bounded organelle • chromatin Biological process • protein localization • viral shedding • abscission • establishment of protein localization • viral capsid secondary envelopment • multivesicular body assembly • cytokinesis • positive regulation of collateral sprouting • cell division • positive regulation of proteolysis • protein transport • cell cycle • ESCRT III complex disassembly • neutrophil degranulation • cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9798	71955
Ensembl	ENSG00000182149	ENSMUSG00000031729
UniProt	P53990	Q9CX00
RefSeq (mRNA)	NM_014761 NM_001270975 NM_001270976 NM_001270977 NM_001270978 NM_001270979	NM_028018 NM_001361562
RefSeq (protein)	NP_001257904 NP_001257905 NP_001257906 NP_001257907 NP_001257908 NP_055576	NP_082294 NP_001348491
Location (UCSC)	Chr 16: 71.85 – 71.93 Mb	Chr 8: 109.67 – 109.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000182149 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031729 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
6. "Entrez Gene: KIAA0174 KIAA0174".

Further reading

• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–246. doi:10.1006/excr.2000.4948. PMID 10942595.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–3318. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human IST1 homolog