KIAA0409

Ribosomal RNA-processing protein 8 is a protein that in humans is encoded by the RRP8 gene.[5][6]

RRP8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZFU
Identifiers
Aliases	RRP8, KIAA0409, NML, ribosomal RNA processing 8, methyltransferase, homolog (yeast), ribosomal RNA processing 8
External IDs	OMIM: 615818 MGI: 1914251 HomoloGene: 5621 GeneCards: RRP8
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.4 Start 6,595,072 bp[1] End 6,603,616 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E3 Start 105,731,730 bp[2] End 105,737,385 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • methyltransferase activity • transferase activity • S-adenosylmethionine-dependent methyltransferase activity • methylated histone binding • GO:0001948 protein binding • RNA binding Cellular component • cell membrane • nucleoplasm • rDNA heterochromatin • chromatin silencing complex • nucleolus • cell nucleus • cytosol Biological process • cellular response to glucose starvation • regulation of transcription, DNA-templated • regulation of transcription by glucose • transcription, DNA-templated • methylation • chromatin silencing at rDNA • intrinsic apoptotic signaling pathway by p53 class mediator • rRNA processing • positive regulation of cell cycle arrest • covalent chromatin modification • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23378	101867
Ensembl	ENSG00000132275	ENSMUSG00000030888
UniProt	O43159	Q9DB85
RefSeq (mRNA)	NM_015324	NM_025897 NM_133951
RefSeq (protein)	NP_056139	NP_080173 NP_598712
Location (UCSC)	Chr 11: 6.6 – 6.6 Mb	Chr 7: 105.73 – 105.74 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000132275 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030888 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
6. "Entrez Gene: KIAA0409 KIAA0409".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ribosomal RNA-processing protein 8 (KIAA0409)