KDM4D

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.[5][6] KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

KDM4D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3DXT, 3DXU, 4D6Q, 4D6R, 4D6S, 4HON, 4HOO, 5FP9, 5F5A, 5FP8, 5FPA, 5FPB, 5FP4, 5F5C
Identifiers
Aliases	KDM4D, JMJD2D, lysine demethylase 4D
External IDs	OMIM: 609766 MGI: 3606484 HomoloGene: 69244 GeneCards: KDM4D
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q21 Start 94,973,709 bp[1] End 94,999,519 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A2 Start 14,462,548 bp[2] End 14,500,482 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • dioxygenase activity • metal ion binding • histone demethylase activity • histone demethylase activity (H3-K9 specific) • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • chromatin binding • damaged DNA binding • chromatin DNA binding • methylated histone binding Cellular component • blood microparticle • cell nucleus • nucleoplasm • site of double-strand break • pericentric heterochromatin • histone methyltransferase complex Biological process • regulation of protein phosphorylation • cellular response to ionizing radiation • regulation of transcription, DNA-templated • positive regulation of chromatin binding • oxidation-reduction process • double-strand break repair via homologous recombination • transcription, DNA-templated • positive regulation of double-strand break repair via nonhomologous end joining • covalent chromatin modification • histone H3-K9 demethylation • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • cellular response to DNA damage stimulus • negative regulation of histone H3-K9 trimethylation • chromatin remodeling Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55693	244694
Ensembl	ENSG00000186280	ENSMUSG00000053914
UniProt	Q6B0I6	Q3U2K5
RefSeq (mRNA)	NM_018039	NM_173433
RefSeq (protein)	NP_060509	NP_775609
Location (UCSC)	Chr 11: 94.97 – 95 Mb	Chr 9: 14.46 – 14.5 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.[7][8] A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.[9]

References

1. GRCh38: Ensembl release 89: ENSG00000186280 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053914 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
6. "Entrez Gene: JMJD2D jumonji domain containing 2D".
7. Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (February 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
8. Stein R (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. Retrieved 24 January 2018.
9. Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development. 145 (4). doi:10.1242/dev.158261. PMID 29453221.

Further reading

• Shin S, Janknecht R (August 2007). "Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D". Biochemical and Biophysical Research Communications. 359 (3): 742–6. doi:10.1016/j.bbrc.2007.05.179. PMID 17555712.
• Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y (May 2006). "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell. 125 (3): 467–81. doi:10.1016/j.cell.2006.03.028. PMID 16603238.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.