KDM4D

Lysine-specific demethylase 4D is an enzyme that in humans is encoded by the KDM4D gene.[5][6] KDM4D belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

KDM4D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM4D, JMJD2D, lysine demethylase 4D
External IDsOMIM: 609766 MGI: 3606484 HomoloGene: 69244 GeneCards: KDM4D
Gene location (Human)
Chr.Chromosome 11 (human)[1]
Band11q21Start94,973,709 bp[1]
End94,999,519 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55693

244694

Ensembl

ENSG00000186280

ENSMUSG00000053914

UniProt

Q6B0I6

Q3U2K5

RefSeq (mRNA)

NM_018039

NM_173433

RefSeq (protein)

NP_060509

NP_775609

Location (UCSC)Chr 11: 94.97 – 95 MbChr 9: 14.46 – 14.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In 2017, messenger RNA from this gene was used in the somatic cell nuclear transfer experiment that produced the first two cloned primates from post-embryonic donor material.[7][8] A similar experiment was carried out to increase the cloning efficiency of bovine species in 2018.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000186280 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053914 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Katoh M, Katoh M (June 2004). "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology. 24 (6): 1623–8. doi:10.3892/ijo.25.3.759. PMID 15138608.
  6. "Entrez Gene: JMJD2D jumonji domain containing 2D".
  7. Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q (February 2018). "Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer". Cell. 172 (4): 881–887.e7. doi:10.1016/j.cell.2018.01.020. PMID 29395327.
  8. Stein R (24 January 2018). "Chinese Scientists Clone Monkeys Using Method That Created Dolly The Sheep". National Public Radio. Retrieved 24 January 2018.
  9. Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y (February 2018). "H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming". Development. 145 (4). doi:10.1242/dev.158261. PMID 29453221.

Further reading


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