Helper-component proteinase

Helper-component proteinase (EC 3.4.22.45, HC-Pro) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Hydrolyses a Gly-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-Gly, in the processing of the potyviral polyprotein
Helper-component proteinase
Identifiers
EC number3.4.22.45
CAS number124566-20-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

This enzyme is present in many potyviruses.

References

  1. Kasschau KD, Carrington JC (May 1995). "Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus". Virology. 209 (1): 268–73. doi:10.1006/viro.1995.1254. PMID 7747479.
  2. Verchot, J. (1998). "Potyvirus helper component proteinase". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. (eds.). Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 677–679.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.