HBQ1

Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.[4][5]

HBQ1
Identifiers
Aliases	HBQ1, HBQ, hemoglobin subunit theta 1
External IDs	OMIM: 142240 MGI: 3613460 HomoloGene: 3895 GeneCards: HBQ1
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 180,459 bp[1] End 181,179 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • iron ion binding • oxygen binding • GO:0001948 protein binding • heme binding • metal ion binding • oxygen carrier activity • peroxidase activity • haptoglobin binding • organic acid binding Cellular component • hemoglobin complex • haptoglobin-hemoglobin complex Biological process • oxygen transport • hydrogen peroxide catabolic process • protein heterooligomerization • cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3049	544763
Ensembl	ENSG00000086506	n/a
UniProt	P09105	Q3U0A6
RefSeq (mRNA)	NM_005331	NM_001033981
RefSeq (protein)	NP_005322	NP_001029153
Location (UCSC)	Chr 16: 0.18 – 0.18 Mb	n/a
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000086506 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood. 73 (5): 1081–104. doi:10.1182/blood.V73.5.1081.1081. PMID 2649166.
5. "Entrez Gene: HBQ1 hemoglobin, theta 1".

Further reading

• Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
• Kim JH, Yu CY, Bailey A, et al. (1989). "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters". Nucleic Acids Res. 17 (14): 5687–700. doi:10.1093/nar/17.14.5687. PMC 318189. PMID 2569721.
• Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells". J. Clin. Invest. 83 (3): 1032–8. doi:10.1172/JCI113944. PMC 303780. PMID 2921315.
• Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH (1988). "Nucleotide sequence of the human theta 1-globin gene". Biochem. Genet. 26 (3–4): 207–11. doi:10.1007/BF00561460. PMID 3408475.
• Hsu SL, Marks J, Shaw JP, et al. (1988). "Structure and expression of the human theta 1 globin gene". Nature. 331 (6151): 94–6. doi:10.1038/331094a0. PMID 3422341.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science. 312 (5777): 1215–7. doi:10.1126/science.1126431. PMID 16728641.