Carbaminohemoglobin

Carbaminohemoglobin (or carbaminohaemoglobin, also known as carbhemoglobin and carbohemoglobin) is a compound of hemoglobin and carbon dioxide, and is one of the forms in which carbon dioxide exists in the blood. Twenty-three percent of carbon dioxide is carried in blood this way (70% is converted into bicarbonate by carbonic anhydrase and then carried in plasma, 7% carried as free CO2, in solution, or plasma).[1]

Mechanism

When carbon dioxide binds to hemoglobin, carbaminohemoglobin is formed, lowering hemoglobin's affinity for oxygen via the Bohr effect. In the absence of oxygen, unbound hemoglobin molecules have a greater chance of becoming carbaminohemoglobin. The Haldane effect relates to the increased affinity of de-oxygenated hemoglobin for H+
: offloading of oxygen to the tissues thus results in increased affinity of the hemoglobin for carbon dioxide, and H+
, which the body wants to get rid of, which can then be transported to the lung for removal.

Hemoglobin can bind to four molecules of carbon dioxide. The carbon dioxide molecules form a carbamate with the four terminal-amine groups of the four protein chains in the deoxy form of the molecule. Thus, one hemoglobin molecule can transport four carbon dioxide molecules back to the lungs, where they are released when the molecule changes back to the oxyhemoglobin form.

gollark: I was talking about anonymized stuff *in general* often being problematic.
gollark: Nobody, I said that was basically okay with an opt-out.
gollark: That's not lying.
gollark: Or just *don't tell everyone everything*.
gollark: I, personally, would prefer some people lying to me without me knowing to everyone knowing the full details of my life or something.

See also

References
  1. Gas Transport in the Blood FIG. 18.11 Carbon dioxide transport
  • Fogiel, M. (2004). Biology Problem Solver. Piscataway, New Jersey: Research & Education Association. p. 431. ISBN 0878915141.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.