Glyoxylate reductase (NADP+)

In enzymology, a glyoxylate reductase (NADP+) (EC 1.1.1.79) is an enzyme that catalyzes the chemical reaction

glycolate + NADP+ glyoxylate + NADPH + H+
glyoxylate reductase (NADP)
Identifiers
EC number1.1.1.79
CAS number37250-17-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Thus, the two substrates of this enzyme are glycolate and NADP+, whereas its 3 products are glyoxylate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NADP+ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP+). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2GCG, 2H1S, and 2Q50.

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References
    • Cartwright LN; Hullin RP (1966). "Purification and properties of two glyoxylate reductases from a species of Pseudomonas". Biochem. J. 101 (3): 781–791. PMC 1270187. PMID 16742459.
    • Kleczkowski LA, Randall DD, Blevins DG (1986). "Purification and characterization of a novel NADPH(NADH)-dependent glyoxylate reductase from spinach leaves. Comparison of immunological properties of leaf glyoxylate reductase and hydroxypyruvate reductase". Biochem. J. 239 (3): 653–9. PMC 1147336. PMID 3548703.


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