Glycerol-3-phosphate oxidase
In enzymology, a glycerol-3-phosphate oxidase (EC 1.1.3.21) is an enzyme that catalyzes the chemical reaction
- sn-glycerol 3-phosphate + O2 glycerone phosphate + H2O2
| glycerol-3-phosphate oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.1.3.21 | ||||||||
| CAS number | 9046-28-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and O2, whereas its two products are glycerone phosphate and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:oxygen 2-oxidoreductase. Other names in common use include glycerol phosphate oxidase, glycerol-1-phosphate oxidase, glycerol phosphate oxidase, L-alpha-glycerophosphate oxidase, alpha-glycerophosphate oxidase, and L-alpha-glycerol-3-phosphate oxidase. This enzyme participates in glycerophospholipid metabolism. It employs one cofactor, FAD.
References
- Gancedo C, Gancedo JM, Sols A (1968). "Glycerol metabolism in yeasts. Pathways of utilization and production". Eur. J. Biochem. 5 (2): 165–72. doi:10.1111/j.1432-1033.1968.tb00353.x. PMID 5667352.
- Koditschek LK, Umbreit WW (1969). "Alpha-glycerophosphate oxidase in Streptococcus faecium F 24". J. Bacteriol. 98 (3): 1063–8. PMC 315296. PMID 5788698.