Glutaminyl-peptide cyclotransferase

In enzymology, a glutaminyl-peptide cyclotransferase (EC 2.3.2.5) is an enzyme that catalyzes the chemical reaction

L-glutaminyl-peptide 5-oxoprolyl-peptide + NH3 or
L-glutamyl-peptide 5-oxoprolyl-peptide + H2O
glutaminyl-peptide cyclotransferase
Identifiers
EC number2.3.2.5
CAS number37257-21-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Hence, this enzyme has one substrate, L-glutaminyl-peptide or L-glutamyl-peptide, and two products, 5-oxoprolyl-peptide and NH3 or H2O. The N-terminal 5-oxoproline residue on the peptide is also commonly known as pyroglutamic acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing). Other names in common use include glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, and glutaminyl-transfer ribonucleate cyclotransferase.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 2AFM, 2AFO, 2AFS, 2AFU, 2AFW, 2AFX, 2AFZ, and 2IWA.

Human gene

QPCT - note that Q is one-letter abbreviation for glutamine, and glutaminyl is the name of the acyl group.

gollark: My Rust programs take an entire 20 seconds to compile and as I'm used to JS this is very irritating.
gollark: PotatOS did that *several* times on CraftOS-PC some time ago.
gollark: I once had `npm`'s audit thing provide something like 300 vulnerability warnings.
gollark: No, that's not very much better.
gollark: Please format less horribly and that seems to be missing line breaks.

References
    • Busby WH, Quackenbush GE, Humm J, Youngblood WW, Kizer JS (1987). "An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes". J. Biol. Chem. 262 (18): 8532–6. PMID 3597387.
    • Fischer WH, Spiess J (1987). "Identification of a mammalian glutaminyl cyclase converting glutaminyl into pyroglutamyl peptides". Proc. Natl. Acad. Sci. U.S.A. 84 (11): 3628–32. doi:10.1073/pnas.84.11.3628. PMC 304928. PMID 3473473.
    • Messer M; Ottesen M (1965). "Isolation and properties of glutamine cyclotransferase of dried papaya latex". C. R. Trav. Lab. Carlsberg. 35: 1–24.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.